The impaired ability of the elderly to mount an efficient immune response after exposure to microbes or vaccines represents a major challenge in protection against pathogens in ageing. Recently studies have shown that stimulation of Toll-like receptors (TLRs), using stimulatory ligands, can enhance vaccine efficacy by a number of mechanisms, including the activation of innate immune cells and the consequent production of inflammatory cytokines.
Gambino Caterina Maria, ., Vasto, S., Ioannou, K., Candore, G., Caruso, C., Farzaneh, F. (2017). Triggering of Toll-like receptors in the elderly. A pilot study relevant for vaccination. In G. Accardi, C. Caruso (a cura di), Proceedings of the Symposium “Updates in Pathobiology: Causality and Chance in Ageing, Age-related diseases and Longevity” (pp. 79-90). Palermo : UNIPAPRESS.
Triggering of Toll-like receptors in the elderly. A pilot study relevant for vaccination
Gambino Caterina Maria;Vasto Sonya;Candore Giuseppina;Caruso Calogero;
2017-01-01
Abstract
The impaired ability of the elderly to mount an efficient immune response after exposure to microbes or vaccines represents a major challenge in protection against pathogens in ageing. Recently studies have shown that stimulation of Toll-like receptors (TLRs), using stimulatory ligands, can enhance vaccine efficacy by a number of mechanisms, including the activation of innate immune cells and the consequent production of inflammatory cytokines.
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