Detectable interleukin-9 plasma levels are associated with impaired cardiopulmonary functional capacity and all-cause mortality in patients with chronic heart failure

Marra, AM; Arcopinto, M; Salzano, A; Bobbio, E; Milano, S; Misiano, G; Ferrara, F; Vriz, O; Napoli, R; Triggiani, V; Perrone-Filardi, P; SaccÃ&nbsp;, F; Giallauria, F; Isidori, AM; Vigorito, C; Bossone, E; Cittadini, A

doi:10.1016/j.ijcard.2016.02.017

Inflammatory activation plays a pivotal role in chronic heart failure (CHF) through the increased expression of pro-inflammatory cytokines [1]. Decreased plasma levels of Interleukin (IL-) 5, IL-7 and Interferon-γ (IFN-γ) and increased levels of IL-9 have been already described in CHF [2], and a negative correlation was also reported between IL-9 and left ventricular ejection fraction (LVEF) [2]. Yet, there are only limited data exploring the association between cytokines and functional capacity in CHF and their prognostic role [3]; therefore, primary end-point of the current study was to evaluate all-cause mortality according to changes in cytokines plasma levels in CHF patients.

Marra, A., Arcopinto, M., Salzano, A., Bobbio, E., Milano, S., Misiano, G., et al. (2016). Detectable interleukin-9 plasma levels are associated with impaired cardiopulmonary functional capacity and all-cause mortality in patients with chronic heart failure. INTERNATIONAL JOURNAL OF CARDIOLOGY, 209, 114-117.

Data di pubblicazione:	2016
Titolo:	Detectable interleukin-9 plasma levels are associated with impaired cardiopulmonary functional capacity and all-cause mortality in patients with chronic heart failure
Autori:	Marra, Alberto M. Arcopinto, Michele Salzano, Andrea Bobbio, Emanuele MILANO, Salvatore MISIANO, Gabriella Ferrara, Francesco Vriz, Olga Napoli, Raffaele Triggiani, Vincenzo Perrone-Filardi, Pasquale SaccÃ , Francesco Giallauria, Francesco Isidori, Andrea M. Vigorito, Carlo Bossone, Eduardo Cittadini, Antonio (Corresponding) mostra contributor esterni nascondi contributor esterni
Citazione:	Marra, A., Arcopinto, M., Salzano, A., Bobbio, E., Milano, S., Misiano, G., et al. (2016). Detectable interleukin-9 plasma levels are associated with impaired cardiopulmonary functional capacity and all-cause mortality in patients with chronic heart failure. INTERNATIONAL JOURNAL OF CARDIOLOGY, 209, 114-117.
Rivista:	INTERNATIONAL JOURNAL OF CARDIOLOGY
Digital Object Identifier (DOI):	http://dx.doi.org/10.1016/j.ijcard.2016.02.017
Abstract:	Inflammatory activation plays a pivotal role in chronic heart failure (CHF) through the increased expression of pro-inflammatory cytokines [1]. Decreased plasma levels of Interleukin (IL-) 5, IL-7 and Interferon-γ (IFN-γ) and increased levels of IL-9 have been already described in CHF [2], and a negative correlation was also reported between IL-9 and left ventricular ejection fraction (LVEF) [2]. Yet, there are only limited data exploring the association between cytokines and functional capacity in CHF and their prognostic role [3]; therefore, primary end-point of the current study was to evaluate all-cause mortality according to changes in cytokines plasma levels in CHF patients.
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