The indolent non-Hodgkin lymphomas (i-NHLs) are characterised by a indolent clinical behaviour with slow growth and prolonged natural history. The watchful waiting (WW) strategy is a frequently employed treatment option in these patients. This implies a strict monitoring by imaging examinations, including 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) and CT. A major concern is radiation exposure due to regularly monitoring by conventional imaging procedures. Several studies have demonstrated the reliability of whole-body magnetic resonance imaging (WB-MRI) for lymphoma staging. WB-MRI could be useful for active surveillance in i-NHLs providing the suspect of disease progression that can be then confirmed by additional diagnostic procedures, including 18F-FDG-PET/CT. The directive 2013/59 by the European Union claims that if a radiation-free imaging technique allows obtaining the same diagnostic results, it should be invariably used. In this setting, WB-MRI may be considered a reasonable option in i-NHLs under WW, replacing imaging modalities that cause exposure to ionising radiations. This will help to reduce the cancer risk in i-NHL patients for whom chemo-/radiotherapy remain the usual treatment options following the usually long WW phase. The scientific community should raise the awareness of the risk of ionising radiations in i-NHLs and the emphasise the need for establishing the proper place of WB-MRI in lymphoma imaging. Key Points: Watchful waiting is a reasonable option in patients with indolent non-Hodgkin lymphomas. Imaging is crucial to monitor patients with indolent non-Hodgkin lymphomas. CT and18F-FDG-PET/CT are commonly used, implying a substantial radiation exposure. WB-MRI is highly reliable in lymphoma staging. WB-MRI may be considered to monitor indolent non-Hodgkin lymphomas under watchful waiting.

Galia, M., Albano, D., Tarella, C., Patti, C., Sconfienza, L., Mulã, A., et al. (2018). Whole body magnetic resonance in indolent lymphomas under watchful waiting: The time is now. EUROPEAN RADIOLOGY, 28, 1187-1193 [10.1007/s00330-017-5071-x].

Whole body magnetic resonance in indolent lymphomas under watchful waiting: The time is now

Galia, Massimo;Albano, Domenico
;
Midiri, Massimo;Lagalla, Roberto
2018-01-01

Abstract

The indolent non-Hodgkin lymphomas (i-NHLs) are characterised by a indolent clinical behaviour with slow growth and prolonged natural history. The watchful waiting (WW) strategy is a frequently employed treatment option in these patients. This implies a strict monitoring by imaging examinations, including 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) and CT. A major concern is radiation exposure due to regularly monitoring by conventional imaging procedures. Several studies have demonstrated the reliability of whole-body magnetic resonance imaging (WB-MRI) for lymphoma staging. WB-MRI could be useful for active surveillance in i-NHLs providing the suspect of disease progression that can be then confirmed by additional diagnostic procedures, including 18F-FDG-PET/CT. The directive 2013/59 by the European Union claims that if a radiation-free imaging technique allows obtaining the same diagnostic results, it should be invariably used. In this setting, WB-MRI may be considered a reasonable option in i-NHLs under WW, replacing imaging modalities that cause exposure to ionising radiations. This will help to reduce the cancer risk in i-NHL patients for whom chemo-/radiotherapy remain the usual treatment options following the usually long WW phase. The scientific community should raise the awareness of the risk of ionising radiations in i-NHLs and the emphasise the need for establishing the proper place of WB-MRI in lymphoma imaging. Key Points: Watchful waiting is a reasonable option in patients with indolent non-Hodgkin lymphomas. Imaging is crucial to monitor patients with indolent non-Hodgkin lymphomas. CT and18F-FDG-PET/CT are commonly used, implying a substantial radiation exposure. WB-MRI is highly reliable in lymphoma staging. WB-MRI may be considered to monitor indolent non-Hodgkin lymphomas under watchful waiting.
2018
Galia, M., Albano, D., Tarella, C., Patti, C., Sconfienza, L., Mulã, A., et al. (2018). Whole body magnetic resonance in indolent lymphomas under watchful waiting: The time is now. EUROPEAN RADIOLOGY, 28, 1187-1193 [10.1007/s00330-017-5071-x].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/249751
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