This review covering literature reports from the beginning of this century to 2016 describes the synthetic pathways, the antitumor activity, the structure-activity relationship and, whenever reported, the possible mechanism of action of 1,3,5-triazine derivatives as well as of their hetero-fused compounds. Many 1,3,5-triazine derivatives, both uncondensed and hetero-fused, have shown remarkable antitumor activities and some of them reached clinical development.

Cascioferro, S., Parrino, B., Spano', V., Carbone, A., Montalbano, A., Barraja, P., et al. (2017). 1,3,5-Triazines: A promising scaffold for anticancer drugs development. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 142, 523-549 [10.1016/j.ejmech.2017.09.035].

1,3,5-Triazines: A promising scaffold for anticancer drugs development

Cascioferro, Stella;Parrino, Barbara;Spanò, Virginia;Carbone, Anna;Montalbano, Alessandra;Barraja, Paola;Diana, Patrizia;Cirrincione, Girolamo
2017-01-01

Abstract

This review covering literature reports from the beginning of this century to 2016 describes the synthetic pathways, the antitumor activity, the structure-activity relationship and, whenever reported, the possible mechanism of action of 1,3,5-triazine derivatives as well as of their hetero-fused compounds. Many 1,3,5-triazine derivatives, both uncondensed and hetero-fused, have shown remarkable antitumor activities and some of them reached clinical development.
2017
http://www.journals.elsevier.com/european-journal-of-medicinal-chemistry/
Cascioferro, S., Parrino, B., Spano', V., Carbone, A., Montalbano, A., Barraja, P., et al. (2017). 1,3,5-Triazines: A promising scaffold for anticancer drugs development. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 142, 523-549 [10.1016/j.ejmech.2017.09.035].
File in questo prodotto:
File Dimensione Formato  
E. J. Med. Chem. 142 (2017) 523-549.pdf

Solo gestori archvio

Dimensione 1.95 MB
Formato Adobe PDF
1.95 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/247797
Citazioni
  • ???jsp.display-item.citation.pmc??? 23
  • Scopus 95
  • ???jsp.display-item.citation.isi??? 100
social impact