This review covering literature reports from the beginning of this century to 2016 describes the synthetic pathways, the antitumor activity, the structure-activity relationship and, whenever reported, the possible mechanism of action of 1,3,5-triazine derivatives as well as of their hetero-fused compounds. Many 1,3,5-triazine derivatives, both uncondensed and hetero-fused, have shown remarkable antitumor activities and some of them reached clinical development.
Cascioferro, S., Parrino, B., Spano', V., Carbone, A., Montalbano, A., Barraja, P., et al. (2017). 1,3,5-Triazines: A promising scaffold for anticancer drugs development. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 142, 523-549 [10.1016/j.ejmech.2017.09.035].
1,3,5-Triazines: A promising scaffold for anticancer drugs development
Cascioferro, Stella;Parrino, Barbara;Spanò, Virginia;Carbone, Anna;Montalbano, Alessandra;Barraja, Paola;Diana, Patrizia;Cirrincione, Girolamo
2017-01-01
Abstract
This review covering literature reports from the beginning of this century to 2016 describes the synthetic pathways, the antitumor activity, the structure-activity relationship and, whenever reported, the possible mechanism of action of 1,3,5-triazine derivatives as well as of their hetero-fused compounds. Many 1,3,5-triazine derivatives, both uncondensed and hetero-fused, have shown remarkable antitumor activities and some of them reached clinical development.
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