The aim of this work is to artificially reproduce scalable cellular-like compartments on a chip, thus realizing specialized small volume systems to study the behaviour of interacting biomolecules by few binding events. In particular, we show an unprecedented solution-based protein-binding assay based on arrays of oil-confined water droplets containing protein targets, labelled ligands and other compounds.
Arrabito, G., Cavaleri, F., Montalbano, V., Vetri, V., Leone, M., Pignataro, B. (2016). Towards bioarrays of cellular-like compartments for monitoring few molecular binding events. In Proceedings of the 6th Euchems Chemistry Congress.
Towards bioarrays of cellular-like compartments for monitoring few molecular binding events
Arrabito, Giuseppe Domenico;Cavaleri, Felicia;MONTALBANO, Vincenza;VETRI, Valeria;LEONE, Maurizio;PIGNATARO, Bruno Giuseppe
2016-01-01
Abstract
The aim of this work is to artificially reproduce scalable cellular-like compartments on a chip, thus realizing specialized small volume systems to study the behaviour of interacting biomolecules by few binding events. In particular, we show an unprecedented solution-based protein-binding assay based on arrays of oil-confined water droplets containing protein targets, labelled ligands and other compounds.
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