Gastrointestinal perforation (GIP) in preterm neonates may be idiopathic, due to necrotizing enterocolitis (NEC), or mechanical obstruction. The predominant cause of GIP in the neonatal period is NEC. Differential diagnosis with congenital malformations, including mesenteric defects leading to internal hernias, is mandatory if the onset is early. We describe two newborns with trans-mesenteric herniation resulting in GIP, and we discuss the presence of possible additional risk factors such as prematurity and predisposing vascular disruption in connective tissue disorders (Ehlers-Danlos syndrome), twinning, and use of assisted reproductive technologies. These cases prompted us to review our exploratory laparotomies performed for intestinal obstruction, complicated/or not with perforation, to identify the frequency of neonatal trans-mesenteric hernias in a referral hospital. The prevalence of GIP and of internal hernia was 25% and 3.3%, respectively. In conclusion, time-onset and particular conditions associated with GIP should lead to a high index of suspicion for internal hernias in order to achieve appropriate diagnosis and therapy.

Schierz, I., Giuffrè, M., Lo Presti, M., Pinello, G., Chiaramonte, C., Agosta Cecala, E., et al. (2016). Early intestinal perforation secondary to congenital mesenteric defects. JOURNAL OF PEDIATRIC SURGERY CASE REPORTS, 8, 10-12 [10.1016/j.epsc.2016.03.004].

Early intestinal perforation secondary to congenital mesenteric defects

GIUFFRE, Mario;CORSELLO, Giovanni
2016-01-01

Abstract

Gastrointestinal perforation (GIP) in preterm neonates may be idiopathic, due to necrotizing enterocolitis (NEC), or mechanical obstruction. The predominant cause of GIP in the neonatal period is NEC. Differential diagnosis with congenital malformations, including mesenteric defects leading to internal hernias, is mandatory if the onset is early. We describe two newborns with trans-mesenteric herniation resulting in GIP, and we discuss the presence of possible additional risk factors such as prematurity and predisposing vascular disruption in connective tissue disorders (Ehlers-Danlos syndrome), twinning, and use of assisted reproductive technologies. These cases prompted us to review our exploratory laparotomies performed for intestinal obstruction, complicated/or not with perforation, to identify the frequency of neonatal trans-mesenteric hernias in a referral hospital. The prevalence of GIP and of internal hernia was 25% and 3.3%, respectively. In conclusion, time-onset and particular conditions associated with GIP should lead to a high index of suspicion for internal hernias in order to achieve appropriate diagnosis and therapy.
2016
Schierz, I., Giuffrè, M., Lo Presti, M., Pinello, G., Chiaramonte, C., Agosta Cecala, E., et al. (2016). Early intestinal perforation secondary to congenital mesenteric defects. JOURNAL OF PEDIATRIC SURGERY CASE REPORTS, 8, 10-12 [10.1016/j.epsc.2016.03.004].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/209564
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