Background: The coexistence of asthma and chronic obstructive pulmonary disease (asthma-COPD overlap syndrome: ACOS) is increasingly recognized but data about its prevalence and long-term mortality are needed. Methods: Prevalence of ACOS and 15-year mortality rates were assessed in 1065 subjects aged>. 65. years, enrolled in the SA.R.A. study, with complete clinical, lung functional and follow-up data. Physical performance, disease-related disability, and health-related quality of life (HRQL) were also evaluated. Results: ACOS was found in 11.1% of subjects (29.4% of those previously diagnosed with COPD and 19.7% of those with asthma). ACOS was positively associated with impaired physical performance, functional ability, and HRQL. Individuals with ACOS had higher mortality rates than controls (7.17 per 100 person-years; mortality rate ratio: 1.83). After adjustment for the main confounders, the risk of all-cause mortality remained significantly increased in subjects with ACOS (HR: 1.82), COPD (HR: 2.12), and restriction (HR: 2.41), but not asthma. Conclusions: Long-term prognosis of ACOS was similar to COPD, and worse than asthma and healthy controls. ACOS had a significant impact on physical performance, functional ability, and HRQL.

Sorino, C., Pedone, C., Scichilone, N. (2016). Fifteen-year mortality of patients with asthma-COPD overlap syndrome. EUROPEAN JOURNAL OF INTERNAL MEDICINE, 34, 72-77-77 [10.1016/j.ejim.2016.06.020].

Fifteen-year mortality of patients with asthma-COPD overlap syndrome

SORINO, Claudio;SCICHILONE, Nicola Alessandro
2016-01-01

Abstract

Background: The coexistence of asthma and chronic obstructive pulmonary disease (asthma-COPD overlap syndrome: ACOS) is increasingly recognized but data about its prevalence and long-term mortality are needed. Methods: Prevalence of ACOS and 15-year mortality rates were assessed in 1065 subjects aged>. 65. years, enrolled in the SA.R.A. study, with complete clinical, lung functional and follow-up data. Physical performance, disease-related disability, and health-related quality of life (HRQL) were also evaluated. Results: ACOS was found in 11.1% of subjects (29.4% of those previously diagnosed with COPD and 19.7% of those with asthma). ACOS was positively associated with impaired physical performance, functional ability, and HRQL. Individuals with ACOS had higher mortality rates than controls (7.17 per 100 person-years; mortality rate ratio: 1.83). After adjustment for the main confounders, the risk of all-cause mortality remained significantly increased in subjects with ACOS (HR: 1.82), COPD (HR: 2.12), and restriction (HR: 2.41), but not asthma. Conclusions: Long-term prognosis of ACOS was similar to COPD, and worse than asthma and healthy controls. ACOS had a significant impact on physical performance, functional ability, and HRQL.
2016
Sorino, C., Pedone, C., Scichilone, N. (2016). Fifteen-year mortality of patients with asthma-COPD overlap syndrome. EUROPEAN JOURNAL OF INTERNAL MEDICINE, 34, 72-77-77 [10.1016/j.ejim.2016.06.020].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/207647
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