Primary cell cultures from fetal rat CNS have been employed to evaluate the effects caused by the addition of serum from patients affected by multiple sclerosis (MS). MS-serum supplemented media caused a decrease in [3H]-thymidine incorporation into the cultures, thus indicating an inhibitory effect on proliferating glial cells. Sera from patients in remission stage of the disease showed an inhibitory effect not significatively lower than those from patients in acute stage. These results suggest that glial cells may be a target of circulating factors present in MS.
Ferraro, D., Salemi, G., Cestelli, A., Chiarini, A., Savettieri, G. (1987). Inhibition of glial proliferation in vitro by serum from patients with multiple sclerosis. ACTA NEUROLOGICA SCANDINAVICA, 76(4), 237-240 [10.1111/j.1600-0404.1987.tb03573.x].
Inhibition of glial proliferation in vitro by serum from patients with multiple sclerosis
FERRARO, Donatella;SALEMI, Giuseppe;CESTELLI, Alessandro;CHIARINI, Alfredo;SAVETTIERI, Giovanni
1987-01-01
Abstract
Primary cell cultures from fetal rat CNS have been employed to evaluate the effects caused by the addition of serum from patients affected by multiple sclerosis (MS). MS-serum supplemented media caused a decrease in [3H]-thymidine incorporation into the cultures, thus indicating an inhibitory effect on proliferating glial cells. Sera from patients in remission stage of the disease showed an inhibitory effect not significatively lower than those from patients in acute stage. These results suggest that glial cells may be a target of circulating factors present in MS.File | Dimensione | Formato | |
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1987 Inhibition of glial proliferation in vitro by serum from patients with multiple sclerosis..pdf
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