Conclusion: HA-g-PDLLA hydrogel is suitable to coat a prosthesis remaining adherent to it and distributing itself in the bone cavity. The hydrogel has been proven effective in a rabbit model of highly contaminated implant. In vivo studies have demonstrated how the intraoperative coating of implants with DAC is safe and feasible. HA-EDA-MA hydrogel is able to protect PEP from alteration during storage and it seems a good candidate for a potential once-daily oral formulation in the treatment of celiac disease.
Palumbo, F.S. (2016). Hyaluronic acid based hydrogels for antibiotics and enzymes release: from academic research to industry. In Abstract Books Thematic workshop of Controlled Release Society Italy Chapter Pharmaceutical Innovations: Academia meets Industry Milano November 3rd-4th , 2016. Controlled Release Society Italy Chapter.
Hyaluronic acid based hydrogels for antibiotics and enzymes release: from academic research to industry
PALUMBO, Fabio Salvatore
;PITARRESI, Giovanna;GIAMMONA, Gaetano
2016-01-01
Abstract
Conclusion: HA-g-PDLLA hydrogel is suitable to coat a prosthesis remaining adherent to it and distributing itself in the bone cavity. The hydrogel has been proven effective in a rabbit model of highly contaminated implant. In vivo studies have demonstrated how the intraoperative coating of implants with DAC is safe and feasible. HA-EDA-MA hydrogel is able to protect PEP from alteration during storage and it seems a good candidate for a potential once-daily oral formulation in the treatment of celiac disease.
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