Abstract Two new ring systems, isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine, were conveniently synthesized through cyclization of suitably substituted isoindole derivatives. Some of the new compounds exhibited antiproliferative activity against a wide range of human tumor cell lines with GI50 mean values at low micromolar level (3.72-5.13 μM).
Parrino, B., Ciancimino, C., Carbone, A., Spanò, V., Montalbano, A., Barraja, P., et al. (2015). Synthesis of isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine: two new ring systems of pharmaceutical interest. TETRAHEDRON, 71(39), 7332-7338 [10.1016/j.tet.2015.04.083].
Synthesis of isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine: two new ring systems of pharmaceutical interest
PARRINO, Barbara;CIANCIMINO, Cristina;CARBONE, Anna;SPANO', Virginia;MONTALBANO, Alessandra;BARRAJA, Paola;CIRRINCIONE, Girolamo;DIANA, Patrizia
2015-01-01
Abstract
Abstract Two new ring systems, isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine, were conveniently synthesized through cyclization of suitably substituted isoindole derivatives. Some of the new compounds exhibited antiproliferative activity against a wide range of human tumor cell lines with GI50 mean values at low micromolar level (3.72-5.13 μM).
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