Objective: Our aims were to analyze the relationship between 25hydroxyvitamin D(25[OH]D) plasma levels and clinical and ambulatory blood pressure (BP) values, and to identify any possible association between hypertension and FokI and BsmI vitamin D receptor (VDR) gene polymorphisms in essential hypertensive patients. Design and method: Seventyone essential hypertensive patients and seventytwo controls, 18–75 years old, were enrolled. Clinical physical examination, routine blood chemistry, clinical BP, 24 hour ambulatory blood pressure monitoring, 25[OH]D and Plasma Renin Activity (PRA) assay, and FokI and BsmI VDR polymorphisms analysis were obtained. Results:We observed a significant negative correlation between 25[OH]D and 24 h systolic BP (r = 0.277, p = 0.043) (Figure 1). This correlation persisted in backward stepwise multivariate analyses (b=0.337; p = 0.022) including as covariates first age, gender, body mass index, glomerular filtration rate estimated (eGFR) by MDRD equation, and secondly PRA. Furthermore body mass index (b=0.290; p = 0.037) and eGFRMDRD (b=0.301; p = 0.038) were independently correlated to 24 h systolic BP. We did not observe statistically significant correlation between 25[OH]D and PRA. When we compared anthropometric, clinical and biohumoral parameters among patients with different VDR (FokI and BsmI) genotypes, we found a significant difference of clinic diastolic BP values among the three FokI genotypes (p = 0.018). Significantly higher diastolic BP values in patients with ff FokI genotype compared with patients with Ff FokI genotype (p = 0.002) were disclosed through the MannWhitney U test. Lastly any association between a specific genotype or allele and hypertension or PRAwas not found when we compared allelic frequencies and genotype distribution between patients and controls. Conclusions: Our findings confirm the relation between 25[OH]D and BP values in essential hypertensive patients and they suggest that FokI and BmsI VDR polymorphisms is not associated either with hypertension or with PRA.
Guglielmo, C., Cottone, S., Guarino, L., Arsena, R., Scazzone, C., Tornese, F., et al. (2015). FOKI AND BSMI VITAMIN D RECEPTOR GENE POLYMORPHISMS, PLASMA RENIN ACTIVITY AND ESSENTIAL ARTERIAL HYPERTENSION. In J Hypertens. 2015 Jun Suppl 1 (pp.510-510). Wolters Kluwer Health.
|Autori:||Guglielmo, C.; Cottone, S.; Guarino, L.; Arsena, R.; Scazzone, C.; Tornese, F.; Guarneri, M.; Bono, A.; Mule', G.|
|Titolo:||FOKI AND BSMI VITAMIN D RECEPTOR GENE POLYMORPHISMS, PLASMA RENIN ACTIVITY AND ESSENTIAL ARTERIAL HYPERTENSION|
|Data di creazione:||2015|
|Nome del convegno:||European Meeting on Hypertension and Cardiovascular Prevention|
|Luogo del convegno:||MILANO|
|Anno del convegno:||12-15 GIUGNO|
|Numero del convegno:||XXV|
|Data di concessione:||2015|
|Data di pubblicazione:||2015|
|Numero di pagine:||1|
|Citazione:||Guglielmo, C., Cottone, S., Guarino, L., Arsena, R., Scazzone, C., Tornese, F., et al. (2015). FOKI AND BSMI VITAMIN D RECEPTOR GENE POLYMORPHISMS, PLASMA RENIN ACTIVITY AND ESSENTIAL ARTERIAL HYPERTENSION. In J Hypertens. 2015 Jun Suppl 1 (pp.510-510). Wolters Kluwer Health.|
|Tipologia:||0 - Proceedings (TIPOLOGIA NON ATTIVA)|
|Appare nelle tipologie:||0 - Proceedings (TIPOLOGIA NON ATTIVA)|