Archivio istituzionale della ricerca dell'Università degli Studi di Palermo
IRIS è il sistema di gestione integrata dei dati della ricerca (persone, pubblicazioni, progetti, attività) adottato dall’Università di Palermo, e ha lo scopo di raccogliere, conservare, documentare, e diffondere ad accesso aperto le informazioni relative alla produzione scientifica degli autori afferenti all’Ateneo.
EnglishOBJECTIVE This study was designed to evaluate the relationship among circulating adiponectin (ADPN), left ventricular mass (LVM) and cardiometabolic comorbidities in subjects at higher global cardiovascular risk (score of “ Cuore Project “) METHODS. 115 consecutive subjects were grouped according to normal or low ADPN levels. Left ventricular internal diameter (LVID/h), total LV mass (LVM), LVM index (LVMI), relative wall thickness (RWT), LV ejection fraction by echocardiography and diastolic parameters, by pulsed-wave Doppler were calculated. RESULTS Low-ADPN subjects were characterized by a significant higher prevalence of some cardiometabolic comorbidities (obesity, visceral obesity, diabetes and insulin resistance, LVH, Metabolic syndrome ( MetS),CAD). BMI (p<0.0001), WHR (p<0.03), triglycerides (p<0,001), HOMA-IR (p<0.001), LVM, LVMI, IVST and RWT (p< 0.0001) were significantly increased and HDL-C (p<0.001) and LVEF were significantly reduced in low-ADPN than normal-ADPN subjects. LVMI correlated directly with BMI (p<0.001), WHR (p<0.001) MBP (p<0.001), MetS (p<0.001) and inversely with ADPN ( p<0.0001). Mutiple regression analysis indicated that ADPN was independently associated to LVMI. CONCLUSIONS ADPN might be considered a key component that mediates the cross-talk between adipose tissue, cardiac cells and the vasculature. Accordingly, its routine measurement might become a new target in the management of global CV risk .
Di Chiara, T., Argano, C., Scaglione, A., Corrao, S., Pinto, A., & Scaglione, R. (2015). Circulating adiponectin: a cardiometabolic marker associated with global cardiovascular risk. ACTA CARDIOLOGICA, 70(1), 33-40 [10.2143/AC.70.1.3064591].
| Data di pubblicazione: | 2015 | |
| Titolo: | Circulating adiponectin: a cardiometabolic marker associated with global cardiovascular risk | |
| Autori: | SCAGLIONE, Rosario (Corresponding) | |
| Citazione: | Di Chiara, T., Argano, C., Scaglione, A., Corrao, S., Pinto, A., & Scaglione, R. (2015). Circulating adiponectin: a cardiometabolic marker associated with global cardiovascular risk. ACTA CARDIOLOGICA, 70(1), 33-40 [10.2143/AC.70.1.3064591]. | |
| Rivista: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.2143/AC.70.1.3064591 | |
| Abstract: | OBJECTIVE This study was designed to evaluate the relationship among circulating adiponectin (ADPN), left ventricular mass (LVM) and cardiometabolic comorbidities in subjects at higher global cardiovascular risk (score of “ Cuore Project “) METHODS. 115 consecutive subjects were grouped according to normal or low ADPN levels. Left ventricular internal diameter (LVID/h), total LV mass (LVM), LVM index (LVMI), relative wall thickness (RWT), LV ejection fraction by echocardiography and diastolic parameters, by pulsed-wave Doppler were calculated. RESULTS Low-ADPN subjects were characterized by a significant higher prevalence of some cardiometabolic comorbidities (obesity, visceral obesity, diabetes and insulin resistance, LVH, Metabolic syndrome ( MetS),CAD). BMI (p<0.0001), WHR (p<0.03), triglycerides (p<0,001), HOMA-IR (p<0.001), LVM, LVMI, IVST and RWT (p< 0.0001) were significantly increased and HDL-C (p<0.001) and LVEF were significantly reduced in low-ADPN than normal-ADPN subjects. LVMI correlated directly with BMI (p<0.001), WHR (p<0.001) MBP (p<0.001), MetS (p<0.001) and inversely with ADPN ( p<0.0001). Mutiple regression analysis indicated that ADPN was independently associated to LVMI. CONCLUSIONS ADPN might be considered a key component that mediates the cross-talk between adipose tissue, cardiac cells and the vasculature. Accordingly, its routine measurement might become a new target in the management of global CV risk . | |
| Settore Scientifico Disciplinare: | Settore MED/09 - Medicina Interna | |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Acta Cardiol 2015.pdf | Articolo principale | N/A | Administrator Richiedi una copia |
http://hdl.handle.net/10447/125152
Copyright © 2022