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EnglishOBJECTIVE This study was designed to evaluate the relationship among circulating adiponectin (ADPN), left ventricular mass (LVM) and cardiometabolic comorbidities in subjects at higher global cardiovascular risk (score of “ Cuore Project “) METHODS. 115 consecutive subjects were grouped according to normal or low ADPN levels. Left ventricular internal diameter (LVID/h), total LV mass (LVM), LVM index (LVMI), relative wall thickness (RWT), LV ejection fraction by echocardiography and diastolic parameters, by pulsed-wave Doppler were calculated. RESULTS Low-ADPN subjects were characterized by a significant higher prevalence of some cardiometabolic comorbidities (obesity, visceral obesity, diabetes and insulin resistance, LVH, Metabolic syndrome ( MetS),CAD). BMI (p<0.0001), WHR (p<0.03), triglycerides (p<0,001), HOMA-IR (p<0.001), LVM, LVMI, IVST and RWT (p< 0.0001) were significantly increased and HDL-C (p<0.001) and LVEF were significantly reduced in low-ADPN than normal-ADPN subjects. LVMI correlated directly with BMI (p<0.001), WHR (p<0.001) MBP (p<0.001), MetS (p<0.001) and inversely with ADPN ( p<0.0001). Mutiple regression analysis indicated that ADPN was independently associated to LVMI. CONCLUSIONS ADPN might be considered a key component that mediates the cross-talk between adipose tissue, cardiac cells and the vasculature. Accordingly, its routine measurement might become a new target in the management of global CV risk .
Di Chiara, T., Argano, C., Scaglione, A., Corrao, S., Pinto, A., & Scaglione, R. (2015). Circulating adiponectin: a cardiometabolic marker associated with global cardiovascular risk. ACTA CARDIOLOGICA, 70(1), 33-40 [10.2143/AC.70.1.3064591].
| Data di pubblicazione: | 2015 | |
| Titolo: | Circulating adiponectin: a cardiometabolic marker associated with global cardiovascular risk | |
| Autori: | SCAGLIONE, Rosario (Corresponding) | |
| Citazione: | Di Chiara, T., Argano, C., Scaglione, A., Corrao, S., Pinto, A., & Scaglione, R. (2015). Circulating adiponectin: a cardiometabolic marker associated with global cardiovascular risk. ACTA CARDIOLOGICA, 70(1), 33-40 [10.2143/AC.70.1.3064591]. | |
| Rivista: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.2143/AC.70.1.3064591 | |
| Abstract: | OBJECTIVE This study was designed to evaluate the relationship among circulating adiponectin (ADPN), left ventricular mass (LVM) and cardiometabolic comorbidities in subjects at higher global cardiovascular risk (score of “ Cuore Project “) METHODS. 115 consecutive subjects were grouped according to normal or low ADPN levels. Left ventricular internal diameter (LVID/h), total LV mass (LVM), LVM index (LVMI), relative wall thickness (RWT), LV ejection fraction by echocardiography and diastolic parameters, by pulsed-wave Doppler were calculated. RESULTS Low-ADPN subjects were characterized by a significant higher prevalence of some cardiometabolic comorbidities (obesity, visceral obesity, diabetes and insulin resistance, LVH, Metabolic syndrome ( MetS),CAD). BMI (p<0.0001), WHR (p<0.03), triglycerides (p<0,001), HOMA-IR (p<0.001), LVM, LVMI, IVST and RWT (p< 0.0001) were significantly increased and HDL-C (p<0.001) and LVEF were significantly reduced in low-ADPN than normal-ADPN subjects. LVMI correlated directly with BMI (p<0.001), WHR (p<0.001) MBP (p<0.001), MetS (p<0.001) and inversely with ADPN ( p<0.0001). Mutiple regression analysis indicated that ADPN was independently associated to LVMI. CONCLUSIONS ADPN might be considered a key component that mediates the cross-talk between adipose tissue, cardiac cells and the vasculature. Accordingly, its routine measurement might become a new target in the management of global CV risk . | |
| Settore Scientifico Disciplinare: | Settore MED/09 - Medicina Interna | |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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http://hdl.handle.net/10447/125152
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