BACKGROUND AND PURPOSE: It is still in debate whether the evaluation of markers of infection and inflammation may be of importance for cerebrovascular and cardiovascular prevention, and we aimed to investigate this field in a prospective 5-year clinical follow-up study in patients with early stages of atherosclerosis. METHODS: We studied 668 subjects divided in 3 groups according to the results of carotid ultrasound examination: (1) normal subjects, if intima-media thickness (IMT) was <0.9 mm; (2) with IMT, if IMT was between 0.9 and 1.5 mm; and (3) with asymptomatic carotid plaque, if IMT was >1.5 mm. Traditional cardiovascular risk factors were investigated, and laboratory analysis included measurement of plasma lipids, fibrinogen, C-reactive protein, IgG antibodies for helicobacter pylori (HP), cytotoxic HP, cytomegalovirus, and chlamydia pneumoniae. RESULTS: Cerebrovascular or cardiovascular events were registered in 18% of patients during the follow-up, and at multivariate analysis we found that the high levels of fibrinogen (P<0.0001) and C-reactive protein (P=0.014), the seropositivity to cytotoxic HP (P=0.001) and chlamydia pneumoniae (P=0.026), the presence of IMT or asymptomatic carotid plaque (P<0.0001), and the total burden of infections (P<0.0001) were the variables predictive of the clinical events. CONCLUSIONS: Beyond traditional cardiovascular risk factors, markers of inflammation and infections seem to significantly influence the occurrence of cerebrovascular and cardiovascular events in patients with baseline asymptomatic carotid lesions.
|Data di pubblicazione:||2004|
|Titolo:||Infection and inflammation influence the outcome of patient with asymptomatic carotid lesions|
|Autori:||CORRADO, E; TANTILLO, R; MURATORI, IM; EVOLA, G; VITALE, G; RIZZO, M; MANSUETO, S; STRANO, A; NOVO, S|
|Tipologia:||Articolo su rivista|
|Citazione:||CORRADO, E., TANTILLO, R., MURATORI, I.M., EVOLA, G., VITALE, G., RIZZO, M., et al. (2004). Infection and inflammation influence the outcome of patient with asymptomatic carotid lesions. INTERNATIONAL ANGIOLOGY, vol.23, Suppl.1.1, 168-168.|
|Appare nelle tipologie:||01 - Articolo su rivista|