Rilevanza clinica delle interazioni farmacologiche di tipo farmacocinetico [Clinical significance of pharmacokinetic interactions]

The correct realization of a pharmacological therapy needs the individuation of the most appropriate drugs for the treatment of the patient's disease. However, even the most effective, and potent and appropriate drugs cannot assure the therapeutic success, if that compound does not reach the site of action. This result can be obtained only if the physician knows the factors that regulate thepharmacokinetic parameters of the used drugs, i.e. absorption, distribution, metabolism, excretion, that regulate the onset velocity, the duration and the intensity of the drug effects. In the lost years, pharmacological interactions, i.e. the possibility that co-administered drugs interfere with each other on the effects, aroused a raising clinical interest. Pharmacological interactions are useful if they augment the therapeutic efficacy of interacting molecules, but they should be avoided if they reduce the therapeutic effects or increase the adverse reactions. The aim of this brief treatment on the clinical significance of pharmacokinetic interactions is to give some useful suggestions for a rational and proper use of pharmacological poly-therapies, on the basis of the pharmacokinetic parameters, in order to promote the patient's health