Background: T-cells expressing the KIR2DS2 activating receptor were found to be prevalent in the coronary culprit atherosclerotic plaque in patients with acute coronary syndromes (ACS), suggesting a possible cytolytic activity against the endothelium of the plaque, leading to plaque rupture and in turn to superimposed thrombosis and sudden occlusion of the artery. To explore if a similar pathogenetic mechanism occurs in acute ischemic stroke, we analyzed the possible association between the genetic KIR and HLA repertoire and the susceptibility to ischemic stroke. Methods: Fourteen patients with ischemic stroke and ten controls with atherosclerotic disease without ischemic stroke matched for sex and age were genotyped for KIR and their HLA ligands, using PCR-SSP. Results: The frequency of the homozygous A haplotype (only KIR2DS4 as activating KIR) was 57% in patients and 80% controls (OR=0.33). The total number of activating and inhibitory KIR was not significantly different between cases and controls. The HLA-A was present in four cases and one control. The HLABw4T and HLABw4I alleles, as well as either the homozygous or the heterozygous form, were present in 12 cases and 6 controls, respectively. The putative interaction between HLABw4T/I allele and the KIR3DL1 inhibitory receptor was reported in 12 cases and 6 controls (OR=4). Conclusions: This descriptive preliminary analysis shows that subjects with ischemic stroke have a lower frequency of the A-haplotype, a higher frequency the HLABw4T or HLABw4I allele and a higher frequency of the HLABw4T/I-KIR3DL1 inhibitory interaction compared to controls, suggesting a stronger potential inhibition on NK activation.
Aiello, A., Accardi, G., Virruso, C., Gambino, C., Candore, G., Tuttolomondo, A., et al. (2014). HLA and KIR Interaction in Patients with Ischemic Stroke. THE AMERICAN JOURNAL OF PATHOLOGY, 184, 34-34.
|Data di pubblicazione:||2014|
|Titolo:||HLA and KIR Interaction in Patients with Ischemic Stroke|
|Citazione:||Aiello, A., Accardi, G., Virruso, C., Gambino, C., Candore, G., Tuttolomondo, A., et al. (2014). HLA and KIR Interaction in Patients with Ischemic Stroke. THE AMERICAN JOURNAL OF PATHOLOGY, 184, 34-34.|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
Settore MED/09 - Medicina Interna
|Appare nelle tipologie:||1.13 Abstract in rivista|