Hormesis is an adaptive stress response implicated in longevity regulation. Schroeder et al. (2013) have now connected stress, epigenetic changes, and aging in yeast by showing that mitochondria-derived reactive oxygen species modulate the chromatin binding capacity of the histone demethylase Rph1p at subtelomeres, resulting in lifespan extension.
Mirisola, M.G., Longo, V.D. (2013). A radical signal activates the epigenetic regulation of longevity. CELL METABOLISM, 17(6), 812-813 [10.1016/j.cmet.2013.05.015.].
A radical signal activates the epigenetic regulation of longevity
MIRISOLA, Mario Giuseppe;
2013-01-01
Abstract
Hormesis is an adaptive stress response implicated in longevity regulation. Schroeder et al. (2013) have now connected stress, epigenetic changes, and aging in yeast by showing that mitochondria-derived reactive oxygen species modulate the chromatin binding capacity of the histone demethylase Rph1p at subtelomeres, resulting in lifespan extension.
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