We report here on the discovery and preliminary evaluation of a novel non-macrocyclic low molecular weight quadruplex-stabilizing chemotype. The lead compounds, based on a furan core, show high G-quadruplex stabilisation and selectivity as well as potent in vitro anti-proliferative activity.
Ohnmacht, S., Varavipour, E., Nanjunda, R., Pazitna, I., Di Vita, G., Gunaratnam, M., et al. (2014). Discovery of new G-quadruplex binding chemotypes. CHEMICAL COMMUNICATIONS, 50, 960-963 [10.1039/c3cc48616h].
Discovery of new G-quadruplex binding chemotypes
DI VITA, Gloria;
2014-01-01
Abstract
We report here on the discovery and preliminary evaluation of a novel non-macrocyclic low molecular weight quadruplex-stabilizing chemotype. The lead compounds, based on a furan core, show high G-quadruplex stabilisation and selectivity as well as potent in vitro anti-proliferative activity.
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