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EnglishWe present a classic interactome bioinformatic analysis and a study on competing endogenous (ce) RNAs for hTERT. The hTERT gene codes for the catalytic subunit and limiting component of the human telomerase complex. Human telomerase reverse transcriptase (hTERT) is essential for the integrity of telomeres. Telomere dysfunctions have been widely reported to be involved in aging, cancer, and cellular senescence. The hTERT gene network has been analyzed using the BioGRID interaction database (http://thebiogrid.org/) and related analysis tools such as Osprey (http://biodata.mshri.on.ca/osprey/servlet/Index) and GeneMANIA (http://genemania.org/). The network of interaction of hTERT transcripts has been further analyzed following the competing endogenous (ce) RNA hypotheses (messenger [m] RNAs cross-talk via micro [mi] RNAs) using the miRWalk database and tools (www.ma.uni-heidelberg.de/apps/zmf/mirwalk/). These analyses suggest a role for Akt, nuclear factor-κB (NF-κB), heat shock protein 90 (HSP90), p70/p80 autoantigen, 14-3-3 proteins, and dynein in telomere functions. Roles for histone acetylation/deacetylation and proteoglycan metabolism are also proposed.
Arancio, W., Pizzolanti, G., Genovese, S., Baiamonte, C., & Giordano, C. (2014). CeRNA and interactome bioinformatic analyses on human telomerase. REJUVENATION RESEARCH, 17(2), 161-167.
| Data di pubblicazione: | 2014 |
| Titolo: | CeRNA and interactome bioinformatic analyses on human telomerase |
| Autori: | |
| Citazione: | Arancio, W., Pizzolanti, G., Genovese, S., Baiamonte, C., & Giordano, C. (2014). CeRNA and interactome bioinformatic analyses on human telomerase. REJUVENATION RESEARCH, 17(2), 161-167. |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1089/rej.2013.1486 |
| Abstract: | We present a classic interactome bioinformatic analysis and a study on competing endogenous (ce) RNAs for hTERT. The hTERT gene codes for the catalytic subunit and limiting component of the human telomerase complex. Human telomerase reverse transcriptase (hTERT) is essential for the integrity of telomeres. Telomere dysfunctions have been widely reported to be involved in aging, cancer, and cellular senescence. The hTERT gene network has been analyzed using the BioGRID interaction database (http://thebiogrid.org/) and related analysis tools such as Osprey (http://biodata.mshri.on.ca/osprey/servlet/Index) and GeneMANIA (http://genemania.org/). The network of interaction of hTERT transcripts has been further analyzed following the competing endogenous (ce) RNA hypotheses (messenger [m] RNAs cross-talk via micro [mi] RNAs) using the miRWalk database and tools (www.ma.uni-heidelberg.de/apps/zmf/mirwalk/). These analyses suggest a role for Akt, nuclear factor-κB (NF-κB), heat shock protein 90 (HSP90), p70/p80 autoantigen, 14-3-3 proteins, and dynein in telomere functions. Roles for histone acetylation/deacetylation and proteoglycan metabolism are also proposed. |
| Settore Scientifico Disciplinare: | Settore BIO/11 - Biologia Molecolare Settore MED/13 - Endocrinologia |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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