Exogenous insulin is, at the moment, the therapy of choice of diabetes, but does not allow tight regulation of glucose leading to long-term complications. Recently, pancreatic islet transplantation to reconstitute insulin-producing cells, has emerged as an alternative promising therapeutic approach. Unfortunately, the number of donor islets is too low compared with the high number of patients needing a transplantation leading to a search for renewable sources of high-quality -cells. This review, summarizes more recent promising approaches to the generation of new -cells from embryonic stem cells for transdifferentiation of adult cells, particularly a critical examination of the seminal work by Lumelsky et al.

Gioviale, M.C., Bellavia, M., Damiano, G., & Lo Monte, A.I. (2013). Beyond islet trasplantation in diabetes cell terapy:from embryonic stem cells to transdifferentation of adult cells. TRANSPLANTATION PROCEEDINGS, 45(5), 2019-2024 [10.1016/j.transproceed.2013.01.076].

Beyond islet trasplantation in diabetes cell terapy:from embryonic stem cells to transdifferentation of adult cells

GIOVIALE, Maria Concetta;BELLAVIA, Maurizio;DAMIANO, Giuseppe;LO MONTE, Attilio Ignazio
2013

Abstract

Exogenous insulin is, at the moment, the therapy of choice of diabetes, but does not allow tight regulation of glucose leading to long-term complications. Recently, pancreatic islet transplantation to reconstitute insulin-producing cells, has emerged as an alternative promising therapeutic approach. Unfortunately, the number of donor islets is too low compared with the high number of patients needing a transplantation leading to a search for renewable sources of high-quality -cells. This review, summarizes more recent promising approaches to the generation of new -cells from embryonic stem cells for transdifferentiation of adult cells, particularly a critical examination of the seminal work by Lumelsky et al.
Settore MED/18 - Chirurgia Generale
Settore BIO/13 - Biologia Applicata
Gioviale, M.C., Bellavia, M., Damiano, G., & Lo Monte, A.I. (2013). Beyond islet trasplantation in diabetes cell terapy:from embryonic stem cells to transdifferentation of adult cells. TRANSPLANTATION PROCEEDINGS, 45(5), 2019-2024 [10.1016/j.transproceed.2013.01.076].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/99262
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