We compared adipokines and inflammatory markers in obese insulin-sensitive (group A, n ¼ 16) and insulin-resistant (group B, n ¼ 48) patients divided according to homeostasis model assessment of insulin resistance (HOMA-IR). Serum levels of adiponectin, leptin, resistin, high-sensitivity C-reactive protein, interleukin 6, and tumor necrosis factor a were measured. Weight, height, waist (WC) and hip circumferences, waist to hip ratio , weight to height ratio, visceral adiposity index (VAI), and body adiposity index (BAI) were measured. The WC and VAI were significantly higher in group B (113.9 + 11.1 vs 105.3 + 9.8cm; P < .01 and 2.3 + 1.1 vs 1.6 + 0.9; P < .05, respectively), while serum adiponectin levels were higher in group A (24.5 + 14.6 vs 15.1 + 9.6 ng/mL; P < .005). The BAI strongly correlated with adiponectin and leptin in group B (r = .479; P < .001 and r = .705; P < .001). Insulin resistance is associated with visceral adiposity described by VAI and WC. The BAI may be a useful index in obese patients, especially with insulin resistance.
Stepien, M., Stepien, A., Wlazel, R.N., Paradowski, M., Rizzo, M., Banach, M., et al. (2014). Predictors of insulin resistance in patients with obesity: a pilot study. ANGIOLOGY, 65, 22-30.
Predictors of insulin resistance in patients with obesity: a pilot study.
RIZZO, Manfredi;
2014-01-01
Abstract
We compared adipokines and inflammatory markers in obese insulin-sensitive (group A, n ¼ 16) and insulin-resistant (group B, n ¼ 48) patients divided according to homeostasis model assessment of insulin resistance (HOMA-IR). Serum levels of adiponectin, leptin, resistin, high-sensitivity C-reactive protein, interleukin 6, and tumor necrosis factor a were measured. Weight, height, waist (WC) and hip circumferences, waist to hip ratio , weight to height ratio, visceral adiposity index (VAI), and body adiposity index (BAI) were measured. The WC and VAI were significantly higher in group B (113.9 + 11.1 vs 105.3 + 9.8cm; P < .01 and 2.3 + 1.1 vs 1.6 + 0.9; P < .05, respectively), while serum adiponectin levels were higher in group A (24.5 + 14.6 vs 15.1 + 9.6 ng/mL; P < .005). The BAI strongly correlated with adiponectin and leptin in group B (r = .479; P < .001 and r = .705; P < .001). Insulin resistance is associated with visceral adiposity described by VAI and WC. The BAI may be a useful index in obese patients, especially with insulin resistance.File | Dimensione | Formato | |
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