Protein-interaction arrays were generated in living cells by the interaction of bait-presenting artificial receptor constructs (bait-PARCs) with micrometer-scaled antibody surface patterns (see figure). This method was applied to simultaneously monitor the interaction kinetics of a prey protein with two distinct bait proteins in individual living cells.
Gandor S, Reisewitz R, Venkatachalapathy M, Arrabito G, Reibner R, Schroeder H, et al. (2013). A Protein-Interaction Array Inside a Living Cell. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, 52, 4790-4794 [10.1002/anie.201209127].
A Protein-Interaction Array Inside a Living Cell
Arrabito, Giuseppe Domenico;
2013-01-01
Abstract
Protein-interaction arrays were generated in living cells by the interaction of bait-presenting artificial receptor constructs (bait-PARCs) with micrometer-scaled antibody surface patterns (see figure). This method was applied to simultaneously monitor the interaction kinetics of a prey protein with two distinct bait proteins in individual living cells.
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