Several natural guaianolides and synthetic derivatives of repin (1) were tested and found to be active against tumor cell replication. Repin (1) and both mono- and di-halohydrin analogues (2, 7-9, 11, 12) showed significant antitumor potency. A more effective compound (17) was obtained by esterificating repin with the paclitaxel side chain
BRUNO M, ROSSELLI S, MAGGIO AM, RACCUGLIA R A, BASTOW K F, LEE K H (2005). Cytotoxic activity of some natural and synthetic guaianolides. JOURNAL OF NATURAL PRODUCTS, 68(7), 1042-1046 [10.1021/np0500575].
Cytotoxic activity of some natural and synthetic guaianolides
BRUNO, Maurizio;ROSSELLI, Sergio;MAGGIO, Antonella Maria;RACCUGLIA, Rosa Angela;
2005-01-01
Abstract
Several natural guaianolides and synthetic derivatives of repin (1) were tested and found to be active against tumor cell replication. Repin (1) and both mono- and di-halohydrin analogues (2, 7-9, 11, 12) showed significant antitumor potency. A more effective compound (17) was obtained by esterificating repin with the paclitaxel side chain
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