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EnglishThe current standard of care (SoC) for chronic hepatitis C, i.e. the combination of a pegylated-interferon (PEG-IFN) with ribavirin (RBV), may activate underlying autoimmune conditions. Particularly, interferon (IFN) has been known to induce or exacerbate autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) in hepatitis C virus patients. We describe a severe, acute-onset antimitochondrial antibody (AMA)-M2 positive AIH appearing during the last weeks of SoC in a woman with chronic hepatitis C and no previous history of autoimmunity, and resolving on protracted steroids. In this context, the relevance of the characterization of the immunoglobulin isotype of portal plasma cells for a more appropriate diagnosis of autoimmune liver diseases can be emphasized.
Macaluso, F., Alessi, N., & Cabibi, D. (2012). Antimitochondrial antibody -M2 positive autoimmune hepatitis during standard of care for chronic hepatitis C. HEPATOLOGY RESEARCH, 42(4), 428-432.
| Data di pubblicazione: | 2012 |
| Titolo: | Antimitochondrial antibody -M2 positive autoimmune hepatitis during standard of care for chronic hepatitis C. |
| Autori: | |
| Citazione: | Macaluso, F., Alessi, N., & Cabibi, D. (2012). Antimitochondrial antibody -M2 positive autoimmune hepatitis during standard of care for chronic hepatitis C. HEPATOLOGY RESEARCH, 42(4), 428-432. |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1111/j.1872-034X.2011.00931.x |
| Abstract: | The current standard of care (SoC) for chronic hepatitis C, i.e. the combination of a pegylated-interferon (PEG-IFN) with ribavirin (RBV), may activate underlying autoimmune conditions. Particularly, interferon (IFN) has been known to induce or exacerbate autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) in hepatitis C virus patients. We describe a severe, acute-onset antimitochondrial antibody (AMA)-M2 positive AIH appearing during the last weeks of SoC in a woman with chronic hepatitis C and no previous history of autoimmunity, and resolving on protracted steroids. In this context, the relevance of the characterization of the immunoglobulin isotype of portal plasma cells for a more appropriate diagnosis of autoimmune liver diseases can be emphasized. |
| Settore Scientifico Disciplinare: | Settore MED/08 - Anatomia Patologica Settore MED/12 - Gastroenterologia |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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| pdf pubblicato hepatology research.pdf | articolo principale | N/A | Open Access Visualizza/Apri |
http://hdl.handle.net/10447/97447
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