Glucagon-like peptide 2 [GLP-2] is a 33-amino acid peptide released from themucosal enteroendocrine L-cells of the intestine. The actions of GLP-2 are transduced by the GLP-2 receptor [GLP-2R], which is localized in the neurons of the enteric nervous system but not in the intestinal epithelium, indicating an indirect mechanism of action. GLP-2 is well known for its trophic role within the intestine and interest in GLP-2 is now reviving based on the approval of the GLP-2R agonist for treatment of short bowel syndrome [SBS]. Recently it also seems to be involved in glucose homeostasis. The aimof this reviewis to outline the importance of neuroendocrine peptides, specifically of GLP-2 in the enteric modulation of the gastrointestinal function and to focus on new works in order to present an innovative picture of GLP-2.

Baldassano, S., & Amato, A. (2014). GLP-2: What do we know? What are we going to discover?. REGULATORY PEPTIDES, 1 [10.1016/j.regpep.2014.09.002.].

GLP-2: What do we know? What are we going to discover?

BALDASSANO, Sara;AMATO, Antonella
2014

Abstract

Glucagon-like peptide 2 [GLP-2] is a 33-amino acid peptide released from themucosal enteroendocrine L-cells of the intestine. The actions of GLP-2 are transduced by the GLP-2 receptor [GLP-2R], which is localized in the neurons of the enteric nervous system but not in the intestinal epithelium, indicating an indirect mechanism of action. GLP-2 is well known for its trophic role within the intestine and interest in GLP-2 is now reviving based on the approval of the GLP-2R agonist for treatment of short bowel syndrome [SBS]. Recently it also seems to be involved in glucose homeostasis. The aimof this reviewis to outline the importance of neuroendocrine peptides, specifically of GLP-2 in the enteric modulation of the gastrointestinal function and to focus on new works in order to present an innovative picture of GLP-2.
Settore BIO/09 - Fisiologia
Baldassano, S., & Amato, A. (2014). GLP-2: What do we know? What are we going to discover?. REGULATORY PEPTIDES, 1 [10.1016/j.regpep.2014.09.002.].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/97264
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