We developed a basic-catalyzed sol-gel procedure that allows to synthesize silica nanoparticles functionalized with Thioflavin-T (ThT). During the synthesis, the formation of the doped silica nanoparticles was monitored by absorbance spectra indicating that the catalyst does not cause the total hydroxylation of the dye. Fluorescence measurements carried out on the ThT doped silica nanoparticles proved the attachment of ThT on silica and Raman spectroscopy provided information about the dye structure.
Spallino, L., Di Carlo, M.G., Agnello, S., Leone, M., Gelardi, F.M., Cannas, M. (2014). Thioflavin-T doped silica nanoparticles by basic-catalyzed sol-gel synthesis. In FUNDAMENTALS AND APPLICATIONS IN SILICA AND ADVANCED DIELECTRICS (SIO2014): X International Symposium on SiO2, Advanced Dielectrics and Related Devices.
Thioflavin-T doped silica nanoparticles by basic-catalyzed sol-gel synthesis
SPALLINO, Luisa;AGNELLO, Simonpietro;LEONE, Maurizio;GELARDI, Franco Mario;CANNAS, Marco
2014-01-01
Abstract
We developed a basic-catalyzed sol-gel procedure that allows to synthesize silica nanoparticles functionalized with Thioflavin-T (ThT). During the synthesis, the formation of the doped silica nanoparticles was monitored by absorbance spectra indicating that the catalyst does not cause the total hydroxylation of the dye. Fluorescence measurements carried out on the ThT doped silica nanoparticles proved the attachment of ThT on silica and Raman spectroscopy provided information about the dye structure.
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