Fricke infused gel matrices offer several features making them suitable for dosimetric applications; among the set here are tissue equivalence, low cost and ease of preparation. Their nuclear magnetic resonance (NMR) relaxation properties can be used as a radiation detector for the dosimetry of beams used in cancer therapy. In recent years neutron capture therapy has been resumed for the treatment of various types of cancer and it requires three-dimensional mapping of the neutron fields. In this work, we investigated this particular application through NMR relaxometry and MR imaging of Fricke gels exposed to neutrons. We analyzed both the R1 and R2 relaxation rates, which relate to the longitudinal T1 and transversal T2 relaxation times. In particular, we found that the relaxation rate R2 does not depend on the neutron fluence, where as the relaxation rate R1 increases linearly with the fluence. The magnetic resonance imaging acquisitions showed that T1-weighted images allow the characterization of samples exposed to different neutron fluences.

Marrale, M., Brai, M., Longo, A., Gallo, S., Tomarchio, E., Tranchina, L., et al. (2014). NMR relaxometry measurements of Fricke gel dosimeters exposed to neutrons. RADIATION PHYSICS AND CHEMISTRY, 104 [10.1016/j.radphyschem.2014.05.049].

NMR relaxometry measurements of Fricke gel dosimeters exposed to neutrons

MARRALE, Maurizio;BRAI, Maria;LONGO, Anna;GALLO, Salvatore;TOMARCHIO, Elio Angelo;TRANCHINA, Luigi;GAGLIARDO, Cesare;
2014

Abstract

Fricke infused gel matrices offer several features making them suitable for dosimetric applications; among the set here are tissue equivalence, low cost and ease of preparation. Their nuclear magnetic resonance (NMR) relaxation properties can be used as a radiation detector for the dosimetry of beams used in cancer therapy. In recent years neutron capture therapy has been resumed for the treatment of various types of cancer and it requires three-dimensional mapping of the neutron fields. In this work, we investigated this particular application through NMR relaxometry and MR imaging of Fricke gels exposed to neutrons. We analyzed both the R1 and R2 relaxation rates, which relate to the longitudinal T1 and transversal T2 relaxation times. In particular, we found that the relaxation rate R2 does not depend on the neutron fluence, where as the relaxation rate R1 increases linearly with the fluence. The magnetic resonance imaging acquisitions showed that T1-weighted images allow the characterization of samples exposed to different neutron fluences.
Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
http://www.sciencedirect.com/science/article/pii/S0969806X14002242
Marrale, M., Brai, M., Longo, A., Gallo, S., Tomarchio, E., Tranchina, L., et al. (2014). NMR relaxometry measurements of Fricke gel dosimeters exposed to neutrons. RADIATION PHYSICS AND CHEMISTRY, 104 [10.1016/j.radphyschem.2014.05.049].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/96301
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