With the high occurrence of cardiovascular disease and increasing numbers of patients requiring vascular access, there is a significant need for smaller-diameter (>6 mm inner diameter) vascular graft that can provide long-term patency. Despite the technological improvements, restenosis and graft thrombosis continue to hamper the success of the implants. Vascular tissue engineering is a new field that has undergone enormous growth over the last decade and has proposed valid solutions for blood vessels repair. The goal of vascular tissue engineering is to produce neovessels and neoorgan tissue from autologous cells using a biodegradable polymer as a scaffold. The most important advantage of tissue-engineered implants is that these tissue can grow, remodel, rebuild, and respond to injury. This review describes the development of polymeric materials over the years and current tissue engineering strategies for the improvement of vascular conduits.

Abruzzo, A., Fiorica, C., Palumbo, V.D., Altomare, R., Damiano, G., Gioviale, M.C., et al. (2014). USING POLYMERIC SCAFFOLDS FOR VASCULAR TISSUE ENGINEERING. INTERNATIONAL JOURNAL OF POLYMER SCIENCE, 2014 [http://dx.doi.org/10.1155/2014/689390].

USING POLYMERIC SCAFFOLDS FOR VASCULAR TISSUE ENGINEERING

ABRUZZO, Alida;FIORICA, Calogero;PALUMBO, Vincenzo Davide;ALTOMARE, Roberta;DAMIANO, Giuseppe;GIOVIALE, Maria Concetta;TOMASELLO, Giovanni;LICCIARDI, Mariano;PALUMBO, Fabio Salvatore;GIAMMONA, Gaetano;LO MONTE, Attilio Ignazio
2014

Abstract

With the high occurrence of cardiovascular disease and increasing numbers of patients requiring vascular access, there is a significant need for smaller-diameter (>6 mm inner diameter) vascular graft that can provide long-term patency. Despite the technological improvements, restenosis and graft thrombosis continue to hamper the success of the implants. Vascular tissue engineering is a new field that has undergone enormous growth over the last decade and has proposed valid solutions for blood vessels repair. The goal of vascular tissue engineering is to produce neovessels and neoorgan tissue from autologous cells using a biodegradable polymer as a scaffold. The most important advantage of tissue-engineered implants is that these tissue can grow, remodel, rebuild, and respond to injury. This review describes the development of polymeric materials over the years and current tissue engineering strategies for the improvement of vascular conduits.
Settore MED/18 - Chirurgia Generale
Settore BIO/13 - Biologia Applicata
Settore BIO/16 - Anatomia Umana
Abruzzo, A., Fiorica, C., Palumbo, V.D., Altomare, R., Damiano, G., Gioviale, M.C., et al. (2014). USING POLYMERIC SCAFFOLDS FOR VASCULAR TISSUE ENGINEERING. INTERNATIONAL JOURNAL OF POLYMER SCIENCE, 2014 [http://dx.doi.org/10.1155/2014/689390].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/95400
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