Several new benzamides 4a-q were synthesized by stirring in pyridine the acid chlorides 3a-q with the appropriate anthranilamide derivatives 2a-g. Some of the synthesized compounds were evaluated for their in vitro antiproliferative activity against a panel of 5 human cell lines (K562 human chronic myelogenous leukemia cells, MCF-7 breast cancer cells, HTC-116 and HT26 colon cancer cells and NCI H460 non-small cell lung cancer cells).
Raffa, D., Maggio, B., Raimondi, M.V., Cusimano, M.G., Amico, G., Carollo, A., et al. (2013). 2-Cinnamamido, 2-(3-phenylpropiolamido), and 2-(3-phenylpropanamido)benzamides: synthesis, antiproliferative activity, and mechanism of action. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 65, 427-435 [http://dx.doi.org/10.1016/j.ejmech.2013.04.068].
2-Cinnamamido, 2-(3-phenylpropiolamido), and 2-(3-phenylpropanamido)benzamides: synthesis, antiproliferative activity, and mechanism of action
RAFFA, Demetrio;MAGGIO, Benedetta;RAIMONDI, Maria Valeria;CUSIMANO, Maria Grazia;AMICO, Giandomenico;DAIDONE, Giuseppe
2013-01-01
Abstract
Several new benzamides 4a-q were synthesized by stirring in pyridine the acid chlorides 3a-q with the appropriate anthranilamide derivatives 2a-g. Some of the synthesized compounds were evaluated for their in vitro antiproliferative activity against a panel of 5 human cell lines (K562 human chronic myelogenous leukemia cells, MCF-7 breast cancer cells, HTC-116 and HT26 colon cancer cells and NCI H460 non-small cell lung cancer cells).
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