A new asymmetric synthesis of the antibiotic Linezolid was performed through a copper-catalyzed Henry reaction as the key step. The use of camphor-derived aminopyridine ligands helped to improve the yields of the chiral precursor and to obtain Linezolid in good overall yield and enantiomeric excess.
PALUMBO PICCIONELLO, A., Pierro, P., Accardo, A., Buscemi, S., Pace, A. (2013). Concise asymmetric synthesis of Linezolid through catalyzed Henry reaction. RSC ADVANCES, 3(3), 24946-24951 [10.1039/c3ra45186k].
Concise asymmetric synthesis of Linezolid through catalyzed Henry reaction.
PALUMBO PICCIONELLO, Antonio;PIERRO, Paola;ACCARDO, Angela;BUSCEMI, Silvestre;PACE, Andrea
2013-01-01
Abstract
A new asymmetric synthesis of the antibiotic Linezolid was performed through a copper-catalyzed Henry reaction as the key step. The use of camphor-derived aminopyridine ligands helped to improve the yields of the chiral precursor and to obtain Linezolid in good overall yield and enantiomeric excess.
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