Dimethyl sulfoxide (DMSO) is an amphipathic molecule widely used to solubilize water-insoluble compounds. In many studies it was reported that DMSO is capable of affecting several biological processes, thus resulting in a potential cause for the misinterpretation of experimental data. Recent papers showed that DMSO modified the brain bioelectric activity in animal models of epilepsy. In an in vivo model of temporal lobe epilepsy in the rat, we examined the effects of different doses (10%, 50% and 100%) of DMSO on the maximal dentate activation (MDA). The results show that DMSO induced a dose-dependent significant reduction of the electrically induced paroxysmal activity.

Carletti, F., Ferraro, G., Rizzo, V., Cannizzaro, C., & Sardo, P. (2013). Antiepileptic effect of dimethyl sulfoxide in a rat model of temporal lobe epilepsy. NEUROSCIENCE LETTERS, 546, 31-35 [10.1016/j.neulet.2013.04.031].

Antiepileptic effect of dimethyl sulfoxide in a rat model of temporal lobe epilepsy.

CARLETTI, Fabio;FERRARO, Giuseppe;RIZZO, Valerio;CANNIZZARO, Carla;SARDO, Pierangelo
2013

Abstract

Dimethyl sulfoxide (DMSO) is an amphipathic molecule widely used to solubilize water-insoluble compounds. In many studies it was reported that DMSO is capable of affecting several biological processes, thus resulting in a potential cause for the misinterpretation of experimental data. Recent papers showed that DMSO modified the brain bioelectric activity in animal models of epilepsy. In an in vivo model of temporal lobe epilepsy in the rat, we examined the effects of different doses (10%, 50% and 100%) of DMSO on the maximal dentate activation (MDA). The results show that DMSO induced a dose-dependent significant reduction of the electrically induced paroxysmal activity.
Settore BIO/09 - Fisiologia
http://www.sciencedirect.com/science/article/pii/S030439401300390X
Carletti, F., Ferraro, G., Rizzo, V., Cannizzaro, C., & Sardo, P. (2013). Antiepileptic effect of dimethyl sulfoxide in a rat model of temporal lobe epilepsy. NEUROSCIENCE LETTERS, 546, 31-35 [10.1016/j.neulet.2013.04.031].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/83510
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