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EnglishThe aim of this work was to study b-defensin 1 (SBD1) and b-defensin 2 (SBD2) genes in Valle del Belice dairy sheep in order to identify polymorphisms that can be utilized as markers of the analyzed genes, and search for the functional effects and roles of the identified polymorphisms (variation of the amino acid sequence of the protein and stability of mRNA molecule). The study was conducted on 300 randomly selected animals belonging to four flocks. A total of seven SNPs were identified, two in SBD1 and five in SBD2. The two SNPs identified in SBD2 coding region, at position 1659 and position 1667, were nonsynonymous, leading to amino acid changes in the protein product. Nevertheless, the functional effects predicted by the two SNPs demonstrated that amino acid substitutions may not have effect on b-defensin 2 protein function. Moreover, we demonstrated that SBD2 mutant sequence shows changes in mRNA secondary structure. These results suggest that identified SNPs could play a role in the modulation of the immune response.
Monteleone, G., Calascibetta, D., Scaturro, M., Galluzzo, P., Palmeri, M., Riggio, V., et al. (2011). Polymorphisms of beta-defensin genes in Valle del Belice dairy sheep. MOLECULAR BIOLOGY REPORTS, 38(8), 5405-5412 [10.1007/s11033-011-0694-5.].
| Data di pubblicazione: | 2011 | |
| Titolo: | Polymorphisms of beta-defensin genes in Valle del Belice dairy sheep | |
| Autori: | ||
| Citazione: | Monteleone, G., Calascibetta, D., Scaturro, M., Galluzzo, P., Palmeri, M., Riggio, V., et al. (2011). Polymorphisms of beta-defensin genes in Valle del Belice dairy sheep. MOLECULAR BIOLOGY REPORTS, 38(8), 5405-5412 [10.1007/s11033-011-0694-5.]. | |
| Rivista: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s11033-011-0694-5. | |
| Abstract: | The aim of this work was to study b-defensin 1 (SBD1) and b-defensin 2 (SBD2) genes in Valle del Belice dairy sheep in order to identify polymorphisms that can be utilized as markers of the analyzed genes, and search for the functional effects and roles of the identified polymorphisms (variation of the amino acid sequence of the protein and stability of mRNA molecule). The study was conducted on 300 randomly selected animals belonging to four flocks. A total of seven SNPs were identified, two in SBD1 and five in SBD2. The two SNPs identified in SBD2 coding region, at position 1659 and position 1667, were nonsynonymous, leading to amino acid changes in the protein product. Nevertheless, the functional effects predicted by the two SNPs demonstrated that amino acid substitutions may not have effect on b-defensin 2 protein function. Moreover, we demonstrated that SBD2 mutant sequence shows changes in mRNA secondary structure. These results suggest that identified SNPs could play a role in the modulation of the immune response. | |
| Settore Scientifico Disciplinare: | Settore AGR/17 - Zootecnica Generale E Miglioramento Genetico | |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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| Monteleone et al., 2011[1].pdf | articolo | N/A | Open Access Visualizza/Apri |
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