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EnglishElderly people show a reduced protection against new infections and a decreased response to vaccines as a consequence of impairment of both cellular and humoral immunity. In this paper we have studied memory/naïve B cells in the elderly, evaluating surface immunoglobulin expression, production of the pro- and anti-inflammatory cytokines, tumor necrosis factor (TNF)-α and interleukin (IL)-10, and presence of somatic hypermutation, focusing on the IgG(+)IgD(-)CD27(-) double negative (DN) B cells that are expanded in the elderly. Our results show that naïve B cells from young donors need a sufficiently strong stimulus to be activated "in vitro", while naïve B cells from old subjects are able to produce IL-10 and TNF-α when stimulated "physiologically" (α-CD40/IL-4), suggesting that these cells might play a role in the control of the immuno-inflammatory environment in the elderly. In addition, in the elderly there is an accumulation of DN B cells with a reduced rate of somatic hypermutation. Thus, DN B lymphocytes may be exhausted cells that are expanded and accumulate as a by-product of persistent stimulation or impaired germinal center formation
Buffa, S., Bulati, M., Pellicano', M., Dunn Walters, D., Wu, Y., Candore, G., et al. (2011). B cell immunosenescence: different features of naive and memory B cells in elderly. BIOGERONTOLOGY, 12, 473-483.
| Data di pubblicazione: | 2011 |
| Titolo: | B cell immunosenescence: different features of naive and memory B cells in elderly |
| Autori: | |
| Citazione: | Buffa, S., Bulati, M., Pellicano', M., Dunn Walters, D., Wu, Y., Candore, G., et al. (2011). B cell immunosenescence: different features of naive and memory B cells in elderly. BIOGERONTOLOGY, 12, 473-483. |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s10522-011-9353-4 |
| Abstract: | Elderly people show a reduced protection against new infections and a decreased response to vaccines as a consequence of impairment of both cellular and humoral immunity. In this paper we have studied memory/naïve B cells in the elderly, evaluating surface immunoglobulin expression, production of the pro- and anti-inflammatory cytokines, tumor necrosis factor (TNF)-α and interleukin (IL)-10, and presence of somatic hypermutation, focusing on the IgG(+)IgD(-)CD27(-) double negative (DN) B cells that are expanded in the elderly. Our results show that naïve B cells from young donors need a sufficiently strong stimulus to be activated "in vitro", while naïve B cells from old subjects are able to produce IL-10 and TNF-α when stimulated "physiologically" (α-CD40/IL-4), suggesting that these cells might play a role in the control of the immuno-inflammatory environment in the elderly. In addition, in the elderly there is an accumulation of DN B cells with a reduced rate of somatic hypermutation. Thus, DN B lymphocytes may be exhausted cells that are expanded and accumulate as a by-product of persistent stimulation or impaired germinal center formation |
| Settore Scientifico Disciplinare: | Settore MED/04 - Patologia Generale |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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http://hdl.handle.net/10447/78872
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