HIV-1 subtype B is the most frequent strain in Sicily. To date, there is no available data about the genetic diversity of HIV-1 viral strains circulating in Sicily among antiretroviral (ARV) naïve subjects and the role of immigration as potential determinant of evolutionary dynamics of HIV-1 molecular epidemiology. For this purpose, HIV-1 polymerase (pol) sequences obtained from 155 ARV naïve individuals from 2004 to 2009 were phylogenetically analysed. The overall rate of HIV-1 non-B infections was 31.0% (n = 48/155), increasing from 7.8% in 2004–2006 to 40.9% in 2009, and about one-third were identified as unique recombinant forms. CRF02_AG was the prevalent non-B clade (n = 28/48, 58.3%), while subtype C-related strains were responsible for about 30% HIV-1 infections. Non-B viruses strictly associated with heterosexual transmission (85.4%) and were mostly found among immigrants (77.1%). Phylogenetic analysis of non-B sequences found in foreign-born subjects was geographically correlated to the respective country of origin. Moreover, the detection of non-B viral variants in the autochthonous population may support an increasing genetic diversity in Sicily as well as a local circulation of HIV strains also uncommon in our country. In Sicily, HIV-1 epidemic is still mostly attributable to the B subtype. Nevertheless, migration and population movements are progressively introducing novel HIV-1 subtypes causing a continuous increase of HIV-1 molecular dynamic at local level. Molecular surveillance is needed to monitor the genetic evolution of HIV-1 epidemic.
Tramuto, F., Maida, C., Bonura, F., Perna, A., & Vitale, F. (2013). Dynamics and molecular evolution of HIV-1 strains in Sicily among antiretroviral naïve patients. INFECTION GENETICS AND EVOLUTION, 16, 290-297 [10.1016/j.meegid.2013.02.012].
|Data di pubblicazione:||2013|
|Titolo:||Dynamics and molecular evolution of HIV-1 strains in Sicily among antiretroviral naïve patients.|
|Citazione:||Tramuto, F., Maida, C., Bonura, F., Perna, A., & Vitale, F. (2013). Dynamics and molecular evolution of HIV-1 strains in Sicily among antiretroviral naïve patients. INFECTION GENETICS AND EVOLUTION, 16, 290-297 [10.1016/j.meegid.2013.02.012].|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.meegid.2013.02.012|
|Settore Scientifico Disciplinare:||Settore MED/42 - Igiene Generale E Applicata|
|Appare nelle tipologie:||1.01 Articolo in rivista|
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