Besides the action on plasma lipid levels, statins show a series of ancillary effects defined as all of their vascular and nonvascular effects independent from the cholesterol reduction. It has been recently hypothesized that one of these ancillary effects could be the improvement of bone health, due to the interference with bone metabolism. This may potentially represent the rationale for statins' use in the treatment of osteoporosis, the most common disease of the bone. Both experimental observations and clinical studies on this topic generated a number of conflicting results; however, the largest randomized clinical trials, the Scandinavian Simvastatin Survival Study (4S), Long Term Intervention with Pravastatin in Ischemic Disease (LIPID), and Heart Protection Study (HPS), indicate that statins do not prevent or reduce fracture risk

Rizzo, M., Rini, G.B. (2006). Statins, fracture risk, and bone remodeling: What is true?. THE AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 332(2), 55-60 [10.1097/00000441-200608000-00001].

Statins, fracture risk, and bone remodeling: What is true?

RIZZO, Manfredi;RINI, Giovam Battista
2006-01-01

Abstract

Besides the action on plasma lipid levels, statins show a series of ancillary effects defined as all of their vascular and nonvascular effects independent from the cholesterol reduction. It has been recently hypothesized that one of these ancillary effects could be the improvement of bone health, due to the interference with bone metabolism. This may potentially represent the rationale for statins' use in the treatment of osteoporosis, the most common disease of the bone. Both experimental observations and clinical studies on this topic generated a number of conflicting results; however, the largest randomized clinical trials, the Scandinavian Simvastatin Survival Study (4S), Long Term Intervention with Pravastatin in Ischemic Disease (LIPID), and Heart Protection Study (HPS), indicate that statins do not prevent or reduce fracture risk
2006
Rizzo, M., Rini, G.B. (2006). Statins, fracture risk, and bone remodeling: What is true?. THE AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 332(2), 55-60 [10.1097/00000441-200608000-00001].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/77664
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