Perinatal manipulations can lead to neurobehavioural changes in the progeny. In this study we investigated, in adolescent male rat offspring, the consequences of a single, intense prenatal stress induced by a 120 min-maternal immobilization at gestational day 16, and of a daily, brief maternal separation from postnatal day 2 until 21, on: unconditioned fear/anxiety-like behaviour in open ﬁeld and in elevated plus-maze; learning performance in the “Can test”, a non-aversive spatial and tactile/visual task; corticosterone plasma levels under basal and stress-induced conditions. Our results indicate that both prenatal stress and maternal separation procedures decrease emotionality and enhance learning performance. Maternal separation potentiates prenatal stress-induced effects in enhancing learning performance. Both basal and stress-induced corticosterone plasma levels are reduced following prenatal stress, maternal separation and the combination of two procedures. These ﬁndings suggest that a single, intense prenatal stress can enhance the adaptive stress-related responses in the progeny, probably due to the involvement of maternal factors. The synergistic fect of prenatal stress and maternal separation on learning performance may be due to a further damping of hypothalamic–pituitary–adrenal axis response in the progeny that better cope with the task administered.
|Data di pubblicazione:||2006|
|Titolo:||SINGLE, INTENSE PRENATAL STRESS DECREASES EMOTIONALITY AND ENHANCES LEARNING PERFORMANCE IN THE ADOLESCENT RAT OFFSPRING: INTERACTION WITH A BRIEF, DAILY, MATERNAL SEPARATION|
|Autori:||CANNIZZARO, C; PLESCIA, F; MARTIRE, M; GAGLIANO, M; CANNIZZARO, G; MANTIA, G; CANNIZZARO, E|
|Tipologia:||Articolo su rivista|
|Citazione:||CANNIZZARO, C., PLESCIA, F., MARTIRE, M., GAGLIANO, M., CANNIZZARO, G., MANTIA, G., et al. (2006). SINGLE, INTENSE PRENATAL STRESS DECREASES EMOTIONALITY AND ENHANCES LEARNING PERFORMANCE IN THE ADOLESCENT RAT OFFSPRING: INTERACTION WITH A BRIEF, DAILY, MATERNAL SEPARATION. BEHAVIOURAL BRAIN RESEARCH, 169, 128-136.|
|Digital Object Identifier (DOI):||10.1016/j.bbr.2005.12.010|
|Appare nelle tipologie:||01 - Articolo su rivista|