In this work, metal-oxide-semiconductor (MOS)-like sensors in which deoxyribonucleic acid (DNA) strands are covalently immobilized either on Si oxide or on a gold surface were electrically characterized. Si oxide fabrication process allowed us to have a surface insensitive to the solution pH. A significant shift in the flat band voltage was measured after single strand DNA immobilization (+0.47 ± 0.04 V) and after the complementary strand binding (+0.07 ± 0.02 V). The results show that DNA sensing can be performed using a MOS structure which can be easily integrated in a more complex design, thus avoiding the problems related to the integration of micro-electrochemical cells.

Libertino, S., Cannella, G., Aiello, V., Busacca, A., Lombardo, S. (2012). Electrical characterization of deoxyribonucleic acid hybridization in metal-oxide-semiconductor-like structures. APPLIED PHYSICS LETTERS, 101 [10.1063/1.4747452].

Electrical characterization of deoxyribonucleic acid hybridization in metal-oxide-semiconductor-like structures

BUSACCA, Alessandro;
2012-01-01

Abstract

In this work, metal-oxide-semiconductor (MOS)-like sensors in which deoxyribonucleic acid (DNA) strands are covalently immobilized either on Si oxide or on a gold surface were electrically characterized. Si oxide fabrication process allowed us to have a surface insensitive to the solution pH. A significant shift in the flat band voltage was measured after single strand DNA immobilization (+0.47 ± 0.04 V) and after the complementary strand binding (+0.07 ± 0.02 V). The results show that DNA sensing can be performed using a MOS structure which can be easily integrated in a more complex design, thus avoiding the problems related to the integration of micro-electrochemical cells.
2012
Libertino, S., Cannella, G., Aiello, V., Busacca, A., Lombardo, S. (2012). Electrical characterization of deoxyribonucleic acid hybridization in metal-oxide-semiconductor-like structures. APPLIED PHYSICS LETTERS, 101 [10.1063/1.4747452].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/76447
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