Hutchinson-Gilford progeria syndrome (HGPS) is a rare human genetic disease that leads to premature ageing and ageing-associated phenotype. HGPS is caused by mutation in the lamin A (LMNA) gene that leads, in affected young individuals, to the generation of progerin, a splicing mutant of lamin A. A bioinformatics analysis of the LMNA gene network of interactions is presented. Lamin A seems to be involved in epigenetic regulation of transcription, chromatin remodelling, DNA repair, with key roles in stemness regulation, normal ageing and telomere functions. The study suggests particular relevance of chromatin remodellers and histones covalent modifiers in the LMNA network. Specifically, HTATIP histone acetylase seems to be of particular relevance in the network.
Arancio, W. (2011). A Bioinformatics Analysis of Lamin A Regulatory Network: a Perspective on Epigenetic Involvement in Hutchinson-Gilford Progeria Syndrome. In Rejuvenation Res. 2011 Aug;14 Suppl 1:S11-45..
Autori: | Arancio, W. |
Titolo: | A Bioinformatics Analysis of Lamin A Regulatory Network: a Perspective on Epigenetic Involvement in Hutchinson-Gilford Progeria Syndrome |
Data di creazione: | 2011 |
Nome del convegno: | Strategies for Engineered Negligible Senescence (SENS) Fifth Conference. August 31-September 4, 2011. Cambridge, United Kingdom. |
Luogo del convegno: | cambridge uk |
Anno del convegno: | August 31-September 4, 2011. |
Data di pubblicazione: | 2011 |
Numero di pagine: | 00 |
Citazione: | Arancio, W. (2011). A Bioinformatics Analysis of Lamin A Regulatory Network: a Perspective on Epigenetic Involvement in Hutchinson-Gilford Progeria Syndrome. In Rejuvenation Res. 2011 Aug;14 Suppl 1:S11-45.. |
Tipologia: | 0 - Proceedings (TIPOLOGIA NON ATTIVA) |
Appare nelle tipologie: | 0 - Proceedings (TIPOLOGIA NON ATTIVA) |
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File | Descrizione | Tipologia | Licenza | |
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A Bioinformatics Analysis of Lamin A Regulatory Network_ a Perspective on Epigenetic Involvement in Hutchinson-Gilford Progeria Syndrome | SENS Research Foundation.pdf | dal sito sens | N/A | Open Access Visualizza/Apri | |
Abstracts of Strategies for Engineered Negl... [Rejuvenation Res. 2011] - PubMed - NCBI.pdf | da pubmed | N/A | Open Access Visualizza/Apri |