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EnglishT lymphocytes are often induced naturally in melanoma patients and infiltrate tumors. Given that gamma delta T cells mediate antigen-specific killing of tumor cells, we studied the representation and the in vitro cytokine production and cytotoxic activity of tumor infiltrating gamma delta T cells from 74 patients with primary melanoma. We found that gamma delta T cells represent the major lymphocyte population infiltrating melanoma, and both V delta 1(+) and V delta 2(+) cells are involved. The majority of melanoma-infiltrating gamma delta cells showed effector memory and terminally-differentiated phenotypes and, accordingly, polyclonal gamma delta T cell lines obtained from tumor-infiltrating immune cells produced IFN-gamma and TNF-alpha and were capable of killing melanoma cell lines in vitro. The cytotoxic capability of V delta 2 cell lines was further improved by pre-treatment of tumor target cells with zoledronate. Moreover, higher rate of gamma delta T cells isolation and percentages of V delta 2 cells correlate with early stage of development of melanoma and absence of metastasis. Altogether, our results suggest that a natural immune response mediated by gamma delta T lymphocytes may contribute to the immunosurveillance of melanoma.
Cordova, A., Toia, F., LA MENDOLA, C., Orlando, V., Meraviglia, S., Rinaldi, G., et al. (2012). Characterization of human γδ T lymphocytes infiltrating primary malignant melanomas. PLOS ONE, 7(11).
| Data di pubblicazione: | 2012 |
| Titolo: | Characterization of human γδ T lymphocytes infiltrating primary malignant melanomas |
| Autori: | |
| Citazione: | Cordova, A., Toia, F., LA MENDOLA, C., Orlando, V., Meraviglia, S., Rinaldi, G., et al. (2012). Characterization of human γδ T lymphocytes infiltrating primary malignant melanomas. PLOS ONE, 7(11). |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1371/journal.pone.0049878 |
| Abstract: | T lymphocytes are often induced naturally in melanoma patients and infiltrate tumors. Given that gamma delta T cells mediate antigen-specific killing of tumor cells, we studied the representation and the in vitro cytokine production and cytotoxic activity of tumor infiltrating gamma delta T cells from 74 patients with primary melanoma. We found that gamma delta T cells represent the major lymphocyte population infiltrating melanoma, and both V delta 1(+) and V delta 2(+) cells are involved. The majority of melanoma-infiltrating gamma delta cells showed effector memory and terminally-differentiated phenotypes and, accordingly, polyclonal gamma delta T cell lines obtained from tumor-infiltrating immune cells produced IFN-gamma and TNF-alpha and were capable of killing melanoma cell lines in vitro. The cytotoxic capability of V delta 2 cell lines was further improved by pre-treatment of tumor target cells with zoledronate. Moreover, higher rate of gamma delta T cells isolation and percentages of V delta 2 cells correlate with early stage of development of melanoma and absence of metastasis. Altogether, our results suggest that a natural immune response mediated by gamma delta T lymphocytes may contribute to the immunosurveillance of melanoma. |
| Settore Scientifico Disciplinare: | Settore MED/04 - Patologia Generale Settore MED/19 - Chirurgia Plastica |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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| cordova et al. 2012.pdf | articolo | N/A | Open Access Visualizza/Apri |
http://hdl.handle.net/10447/74545
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