AIMS: To examine the protein oxidation, marker of the oxidative stress, in metabolic syndrome (MS). METHODS: We enrolled 106 subjects (45 women and 61 men) with MS of which 43 (14 women and 27 men) were with diabetes mellitus and 63 (31 women and 32 men) were without diabetes mellitus, and 54 subjects (19 women and 35 men) as control group. The protein oxidation, expressed as carbonyl groups, was measured by an enzyme-like immunosorbent assay (ELISA) kit (BioCell PC test kit, Enzo Life Sciences AG, Switzerland). RESULTS: In the whole group of MS subjects, in comparison with control group, a significant increase in carbonyl groups was present. The same datum was also evident between control group and diabetic subjects with MS and between control group and nondiabetic subjects with MS. No difference was observed between the two subgroups (diabetic and nondiabetic subjects with MS) about NOx. Few information were obtained examining the linear regression among carbonyl groups, age, BMI, waist circumference, blood pressure values and metabolic pattern of MS subjects. CONCLUSIONS: In MS subject we observed an increase of protein oxidation not influenced by diabetes mellitus. Several strategies may be employed to reduce this parameter.

Caimi, G., Hopps, E., Noto, D., Canino, B., Montana, M., Lucido, D., et al. (2013). Protein oxidation in a group of subjects with metabolic syndrome. DIABETES & METABOLIC SYNDROME, 7, 38-41 [10.1016/j.dsx.2013.02.013].

Protein oxidation in a group of subjects with metabolic syndrome.

CAIMI, Gregorio;HOPPS, Eugenia;NOTO, Davide;CANINO, Baldassare;LUCIDO, Daniela;LO PRESTI, Rosalia;AVERNA, Maurizio
2013

Abstract

AIMS: To examine the protein oxidation, marker of the oxidative stress, in metabolic syndrome (MS). METHODS: We enrolled 106 subjects (45 women and 61 men) with MS of which 43 (14 women and 27 men) were with diabetes mellitus and 63 (31 women and 32 men) were without diabetes mellitus, and 54 subjects (19 women and 35 men) as control group. The protein oxidation, expressed as carbonyl groups, was measured by an enzyme-like immunosorbent assay (ELISA) kit (BioCell PC test kit, Enzo Life Sciences AG, Switzerland). RESULTS: In the whole group of MS subjects, in comparison with control group, a significant increase in carbonyl groups was present. The same datum was also evident between control group and diabetic subjects with MS and between control group and nondiabetic subjects with MS. No difference was observed between the two subgroups (diabetic and nondiabetic subjects with MS) about NOx. Few information were obtained examining the linear regression among carbonyl groups, age, BMI, waist circumference, blood pressure values and metabolic pattern of MS subjects. CONCLUSIONS: In MS subject we observed an increase of protein oxidation not influenced by diabetes mellitus. Several strategies may be employed to reduce this parameter.
Caimi, G., Hopps, E., Noto, D., Canino, B., Montana, M., Lucido, D., et al. (2013). Protein oxidation in a group of subjects with metabolic syndrome. DIABETES & METABOLIC SYNDROME, 7, 38-41 [10.1016/j.dsx.2013.02.013].
File in questo prodotto:
File Dimensione Formato  
protein oxidation.pdf

non disponibili

Descrizione: Articolo
Dimensione 155.68 kB
Formato Adobe PDF
155.68 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/73872
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 11
  • ???jsp.display-item.citation.isi??? ND
social impact