Patients with genotype 1 chronic hepatitis C (G1 CHC) frequently develop steatosis and insulin resistance (IR), caused by metabolic and viral factors. These accelerate the progression of liver disease and reduce the response to therapy. A sustained virologic response (SVR) to therapy in patients with G1 CHC is associated strongly with polymorphisms near the interleukin-28B (IL28B) gene, but the interaction between IL28B genotype and IR, and their combined effects on SVR, have not been defined. We tested the association between the IL28B rs12979860 single-nucleotide polymorphism and metabolic features, including IR, and evaluated their effects on SVR.

Petta, S., Rosso, C., Leung, R., Abate, M., Booth, D., Salomone, F., et al. (2013). Effects of IL28B rs12979860 CC genotype on metabolic profile and sustained virologic response in patients with genotype 1 chronic hepatitis C. CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 11(3), 311-317.e1 [10.1016/j.cgh.2012.11.022].

Effects of IL28B rs12979860 CC genotype on metabolic profile and sustained virologic response in patients with genotype 1 chronic hepatitis C

GRIMAUDO, Stefania;CAMMA', Calogero;CRAXI, Antonio;
2013

Abstract

Patients with genotype 1 chronic hepatitis C (G1 CHC) frequently develop steatosis and insulin resistance (IR), caused by metabolic and viral factors. These accelerate the progression of liver disease and reduce the response to therapy. A sustained virologic response (SVR) to therapy in patients with G1 CHC is associated strongly with polymorphisms near the interleukin-28B (IL28B) gene, but the interaction between IL28B genotype and IR, and their combined effects on SVR, have not been defined. We tested the association between the IL28B rs12979860 single-nucleotide polymorphism and metabolic features, including IR, and evaluated their effects on SVR.
Petta, S., Rosso, C., Leung, R., Abate, M., Booth, D., Salomone, F., et al. (2013). Effects of IL28B rs12979860 CC genotype on metabolic profile and sustained virologic response in patients with genotype 1 chronic hepatitis C. CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 11(3), 311-317.e1 [10.1016/j.cgh.2012.11.022].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/73825
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