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EnglishNanogels (NGs), or small particles formed by physically or chemically crosslinked polymer networks, represent a niche in the development of “smart” nanoparticles for drug delivery and diagnostics. They offer unique advantages over other systems, including a large and flexible surface for multivalent bio-conjugation; an internal 3D aqueous environment for incorporation and protection of (bio)molecular drugs; the possibility to entrap active metal or mineral cores for imaging or phototherapeutic purposes; stimuli-responsiveness to achieve temporal and/or site control of the release function and biocompatibility. The availability of inexpensive and robust preparation methodologies is at the basis of the development of effective nanogel-based theragnostic devices. The design rules for mass fabrication of nanoscale hydrogel particles with the recourse to industrial-type accelerators is here discussed.
Dispenza, C., Sabatino, M., Grimaldi, N., Spadaro, G., Bulone, D., Bondì, M., et al. (2012). Large-scale Radiation Manufacturing of Hierarchically Assembled Nanogels. In E. Bardone, A. Brucato, & T. Keshavarz (a cura di), CHEMICAL ENGINEERING TRANSACTIONS (pp. 229-234).
| Data di pubblicazione: | 2012 |
| Titolo: | Large-scale Radiation Manufacturing of Hierarchically Assembled Nanogels |
| Autori: | |
| Citazione: | Dispenza, C., Sabatino, M., Grimaldi, N., Spadaro, G., Bulone, D., Bondì, M., et al. (2012). Large-scale Radiation Manufacturing of Hierarchically Assembled Nanogels. In E. Bardone, A. Brucato, & T. Keshavarz (a cura di), CHEMICAL ENGINEERING TRANSACTIONS (pp. 229-234). |
| Abstract: | Nanogels (NGs), or small particles formed by physically or chemically crosslinked polymer networks, represent a niche in the development of “smart” nanoparticles for drug delivery and diagnostics. They offer unique advantages over other systems, including a large and flexible surface for multivalent bio-conjugation; an internal 3D aqueous environment for incorporation and protection of (bio)molecular drugs; the possibility to entrap active metal or mineral cores for imaging or phototherapeutic purposes; stimuli-responsiveness to achieve temporal and/or site control of the release function and biocompatibility. The availability of inexpensive and robust preparation methodologies is at the basis of the development of effective nanogel-based theragnostic devices. The design rules for mass fabrication of nanoscale hydrogel particles with the recourse to industrial-type accelerators is here discussed. |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.3303/CET1227039 |
| Settore Scientifico Disciplinare: | Settore CHIM/07 - Fondamenti Chimici Delle Tecnologie |
| Appare nelle tipologie: | 2.01 Capitolo o Saggio |
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http://hdl.handle.net/10447/73661
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