Hepatocellular carcinoma (HCC) is a major health problem. The treatment of HCC depends on the tumour stage and on the severity of underlying cirrhosis, however, a majority of HCC patients have advanced disease at presentation. In recent years extra-hepatic spread (ES) of HCC seems to have been observed more frequently than in the past even if few data exist in literature on prevalence, clinical presentation and prognosis of patients with HCC ES. Aim of this brief review is underline the main concerns, pitfalls and warnings in practicing with these patients. ES of HCC are not rare, and the probability of finding ES is higher in patients with advanced intra-hepatic HCC. The more frequent ES sites are lung lymph nodes and bones, but also the head and neck district can be affected. The prognosis of HCC patients with ES is poor and sorafenib seems to be the only therapeutic option.

Cabibbo, G., Compilato, D., Genco, C., & Campisi, G. (2012). Extrahepatic spread of hepatocellular carcinoma. PANMINERVA MEDICA, 54(4), 313-322.

Extrahepatic spread of hepatocellular carcinoma

CABIBBO, Giuseppe;COMPILATO, Domenico;GENCO, Chiara;CAMPISI, Giuseppina
2012

Abstract

Hepatocellular carcinoma (HCC) is a major health problem. The treatment of HCC depends on the tumour stage and on the severity of underlying cirrhosis, however, a majority of HCC patients have advanced disease at presentation. In recent years extra-hepatic spread (ES) of HCC seems to have been observed more frequently than in the past even if few data exist in literature on prevalence, clinical presentation and prognosis of patients with HCC ES. Aim of this brief review is underline the main concerns, pitfalls and warnings in practicing with these patients. ES of HCC are not rare, and the probability of finding ES is higher in patients with advanced intra-hepatic HCC. The more frequent ES sites are lung lymph nodes and bones, but also the head and neck district can be affected. The prognosis of HCC patients with ES is poor and sorafenib seems to be the only therapeutic option.
Settore MED/28 - Malattie Odontostomatologiche
Settore MED/12 - Gastroenterologia
www.minervamedica.it
Cabibbo, G., Compilato, D., Genco, C., & Campisi, G. (2012). Extrahepatic spread of hepatocellular carcinoma. PANMINERVA MEDICA, 54(4), 313-322.
File in questo prodotto:
File Dimensione Formato  
extrahpatic spread of hepatocellular carcinoma.pdf

accesso aperto

Dimensione 548.65 kB
Formato Adobe PDF
548.65 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/73318
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 2
social impact