Alzheimer disease (AD) and metabolic syndrome are two highly prevalent pathological conditions of Western society due to incorrect diet, lifestyle, and vascular risk factors. Recent data have suggested metabolic syndrome as an independent risk factor for AD and pre-AD syndrome. Furthermore, biological plausibility for this relationship has been framed within the “metabolic cognitive syndrome” concept. Due to the increasing aging of populations, prevalence of AD in Western industrialized countries will rise in the near future. Thus, new knowledge in the area of molecular biology and epigenetics will probably help to make an early molecular diagnosis of dementia. An association between metabolic syndrome and specific single-nucleotide polylmorphisms (SNPs) in the gene INPPL1, encoding for SHIP2, a SH2 domain-containing inositol 5-phosphatase involved in insulin signaling, has been described. According to recent data suggesting that Type 2 diabetes represents an independent risk factor for AD and pre-AD, preliminary results of a case–control study performed to test the putative association between three SNPs in the SHIP2 gene and AD show a trend toward association of these SNPs with AD.

Accardi, G., Caruso, C., Colonna Romano, G., Camarda, C., Monastero, R., & Candore, G. (2012). Can Alzheimer disease be a form of type 3 diabetes?. REJUVENATION RESEARCH, 15(2), 217-221 [10.1089/rej.2011.1289].

Can Alzheimer disease be a form of type 3 diabetes?

ACCARDI, Giulia;CARUSO, Calogero;COLONNA ROMANO, Giuseppina;CAMARDA, Cecilia;MONASTERO, Roberto
Supervision
;
CANDORE, Giuseppina
2012

Abstract

Alzheimer disease (AD) and metabolic syndrome are two highly prevalent pathological conditions of Western society due to incorrect diet, lifestyle, and vascular risk factors. Recent data have suggested metabolic syndrome as an independent risk factor for AD and pre-AD syndrome. Furthermore, biological plausibility for this relationship has been framed within the “metabolic cognitive syndrome” concept. Due to the increasing aging of populations, prevalence of AD in Western industrialized countries will rise in the near future. Thus, new knowledge in the area of molecular biology and epigenetics will probably help to make an early molecular diagnosis of dementia. An association between metabolic syndrome and specific single-nucleotide polylmorphisms (SNPs) in the gene INPPL1, encoding for SHIP2, a SH2 domain-containing inositol 5-phosphatase involved in insulin signaling, has been described. According to recent data suggesting that Type 2 diabetes represents an independent risk factor for AD and pre-AD, preliminary results of a case–control study performed to test the putative association between three SNPs in the SHIP2 gene and AD show a trend toward association of these SNPs with AD.
Settore MED/04 - Patologia Generale
Settore MED/26 - Neurologia
Accardi, G., Caruso, C., Colonna Romano, G., Camarda, C., Monastero, R., & Candore, G. (2012). Can Alzheimer disease be a form of type 3 diabetes?. REJUVENATION RESEARCH, 15(2), 217-221 [10.1089/rej.2011.1289].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/73210
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