The design through energy-based pharmacophore virtual screening has led to aminocyanopyridine derivatives as efficacious new inhibitors of Hsp90. The synthesized compounds showed a good affinity for the Hsp90 ATP binding site in the competitive binding assay. Moreover, they showed an excellent antiproliferative activity against a large number of human tumor cell lines. Further biological studies on the derivative with the higher EC50 confirmed its specific influence on the cellular pathways involving Hsp90.

Lauria, A., Abbate, I., Gentile, C., Angileri, F., Martorana, A., & Almerico, A.M. (2013). Synthesis and biological activities of a new class of heat shock protein 90 inhibitors, designed by energy-based pharmacophore virtual screening. JOURNAL OF MEDICINAL CHEMISTRY, 56(8), 3424-3428 [10.1021/jm4002023].

Synthesis and biological activities of a new class of heat shock protein 90 inhibitors, designed by energy-based pharmacophore virtual screening

LAURIA, Antonino;GENTILE, Carla;ANGILERI, Francesca;MARTORANA, Annamaria;ALMERICO, Anna Maria
2013

Abstract

The design through energy-based pharmacophore virtual screening has led to aminocyanopyridine derivatives as efficacious new inhibitors of Hsp90. The synthesized compounds showed a good affinity for the Hsp90 ATP binding site in the competitive binding assay. Moreover, they showed an excellent antiproliferative activity against a large number of human tumor cell lines. Further biological studies on the derivative with the higher EC50 confirmed its specific influence on the cellular pathways involving Hsp90.
Settore CHIM/08 - Chimica Farmaceutica
Settore BIO/10 - Biochimica
Lauria, A., Abbate, I., Gentile, C., Angileri, F., Martorana, A., & Almerico, A.M. (2013). Synthesis and biological activities of a new class of heat shock protein 90 inhibitors, designed by energy-based pharmacophore virtual screening. JOURNAL OF MEDICINAL CHEMISTRY, 56(8), 3424-3428 [10.1021/jm4002023].
File in questo prodotto:
File Dimensione Formato  
13-JMC3424.pdf

non disponibili

Descrizione: Articolo principale
Dimensione 1.11 MB
Formato Adobe PDF
1.11 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/73051
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 18
  • ???jsp.display-item.citation.isi??? 19
social impact