The association between osteoporosis and jawbones remains an argument of debate. Both osteoporosis and periodontal diseases are bone resorptive diseases; it has been hypothesized that osteoporosis could be a risk factor for the progression of periodontal disease and vice versa. Hypothetical models linking the two conditions exist: in particular, it is supposed that the osteoporosis-related bone mass density reduction may accelerate alveolar bone resorption caused by periodontitis, resulting in a facilitated periodontal bacteria invasion. Invading bacteria, in turn, may alter the normal homeostasis of bone tissue, increasing osteoclastic activity and reducing local and systemic bone density by both direct effects (release of toxins) and/or indirect mechanisms (release of inflammatory mediators). Current evidence provides conflicting results due to potential biases related to study design, samples size and endpoints. The aim of this article is to review and summarize the published literature on the associations between osteoporosis and different oral conditions such as bone loss in the jaws, periodontal diseases, and tooth loss. Further well-controlled studies are needed to better elucidate the inter-relationship between systemic and oral bone loss and to clarify whether dentists could usefully provide early warning for osteoporosis risk.

Guiglia, R., Di Fede, O., Lo Russo, L., Sprini, D., Rini, G.B., & Campisi, G. (2013). Osteoporosis, jawbones and periodontal disease. MEDICINA ORAL, PATOLOGÍA ORAL Y CIRUGÍA BUCAL, 18, 93-99 [http://dx.doi.org/doi:10.4317/medoral.18298].

Osteoporosis, jawbones and periodontal disease

GUIGLIA, Rosario;DI FEDE, Olga;SPRINI, Delia;RINI, Giovam Battista;CAMPISI, Giuseppina
2013

Abstract

The association between osteoporosis and jawbones remains an argument of debate. Both osteoporosis and periodontal diseases are bone resorptive diseases; it has been hypothesized that osteoporosis could be a risk factor for the progression of periodontal disease and vice versa. Hypothetical models linking the two conditions exist: in particular, it is supposed that the osteoporosis-related bone mass density reduction may accelerate alveolar bone resorption caused by periodontitis, resulting in a facilitated periodontal bacteria invasion. Invading bacteria, in turn, may alter the normal homeostasis of bone tissue, increasing osteoclastic activity and reducing local and systemic bone density by both direct effects (release of toxins) and/or indirect mechanisms (release of inflammatory mediators). Current evidence provides conflicting results due to potential biases related to study design, samples size and endpoints. The aim of this article is to review and summarize the published literature on the associations between osteoporosis and different oral conditions such as bone loss in the jaws, periodontal diseases, and tooth loss. Further well-controlled studies are needed to better elucidate the inter-relationship between systemic and oral bone loss and to clarify whether dentists could usefully provide early warning for osteoporosis risk.
Settore MED/28 - Malattie Odontostomatologiche
Settore MED/09 - Medicina Interna
10.4317/medoral.18298
Guiglia, R., Di Fede, O., Lo Russo, L., Sprini, D., Rini, G.B., & Campisi, G. (2013). Osteoporosis, jawbones and periodontal disease. MEDICINA ORAL, PATOLOGÍA ORAL Y CIRUGÍA BUCAL, 18, 93-99 [http://dx.doi.org/doi:10.4317/medoral.18298].
File in questo prodotto:
File Dimensione Formato  
osteoporosis jawbones and periodontal disease.pdf

accesso aperto

Dimensione 430.31 kB
Formato Adobe PDF
430.31 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/71700
Citazioni
  • ???jsp.display-item.citation.pmc??? 33
  • Scopus 75
  • ???jsp.display-item.citation.isi??? 69
social impact