In-silico multi-physics model to assist biomimetic polymeric mitral valve Double Component Deposition (DCD) processing

Engineering the mitral valve (MV) leaflets poses unique functional and structural challenges: leaflet asymmetry, thickness variation, and mitral dynamism render most polymer fabrication techniques ineffective. We developed Double Component Deposition (DCD) to prescribe scaffold anisotropy, fiber diameter, leaflet thickness, size, and shape. This work advances DCD with multiphysics analyses of fiber deposition mechanisms. Electrical field (EF) distribution allowed the identification of optimal surface Double Component Ratio (DCRs) for the collecting target, while fluid mechanics defined a mandrel rotation axis for anisotropic fabrication. These enhancements improved engineered MV accuracy in thickness distribution and anisotropy.