Effect of Periodontal Treatment on Metabolic Syndrome Parameters: A Systematic Review

AimTo evaluate the effects of periodontal treatment on metabolic syndrome (MS) parameters and systemic inflammatory biomarker levels in patients affected by both MS and periodontitis.MethodsA systematic search was conducted to identify randomized controlled trials (RCTs) with a follow-up >= 1 month comparing a more intense periodontal treatment (test intervention) to either a less intense or no periodontal treatment (control intervention). MS parameters such as triglycerides (TG), high-density lipoprotein cholesterol (HDL), fasting blood glucose (FBG), glycated hemoglobin (HbA1c), systolic blood pressure (SBP), diastolic blood pressure (DBP), waist circumference (WC), and systemic inflammatory biomarkers (i.e., C-reactive protein, CRP) were analyzed. Random-effects meta-regression analyses were conducted at 3- and 6-month follow-ups.ResultsFour RCTs were included. Test intervention resulted in a statistically significant greater SBP reduction at 3 (WMD 1.48) and 6 (WMD 1.88) months compared to control group. A statistically significant difference between groups was observed for FBG at 6 months after treatment, favoring test intervention (WMD 0.61). No differences were observed for the other MS parameters and for CRP at both 3- and 6-month follow-up.ConclusionsPeriodontal treatment seems to have beneficial effects on SBP and FBG in patients with MS and periodontitis at 3-6-month follow-ups.Trial RegistrationThis systematic review was registered under the protocol registration number CRD42024499854/PROSPERO