Specific tumor-derived extracellular vesicles, called exosomes, are considered as potential key players in cross-talk between immune system and tumor microenvironment in several solid tumors. Different studies highlighted the clinical relevance of exosomes in ovarian cancer (OC) for their role in early diagnosis, prognosis, chemoresistance, targeted therapy. The exosomes are nanosize vesicles carrying lipids, proteins, and nucleic acids. In particular, exosomes shuttle a wide spectrum of microRNAs (miRNAs) able to induce phenotypic reprogramming of target cells, contributing to tumor progression. In this review, we will discuss the promising role of miRNAs shuttled by exosomes, called exosomal miRNAs (exo-miRNAs), as potential biomarkers for early detection, tumour progression and metastasis, prognosis, and response to therapy in OC women, in order to search for new potential biological fingerprints able to better characterize the evolution of this malignancy and provide a clinically relevant non-invasive approach useful for adopting, in future, personalized therapeutic strategies.

Fanale, D., Corsini, L.R., Bono, M., Randazzo, U., Barraco, N., Brando, C., et al. (2024). Clinical relevance of exosome-derived microRNAs in Ovarian Cancer: Looking for new tumor biological fingerprints [10.1016/j.critrevonc.2023.104220].

Clinical relevance of exosome-derived microRNAs in Ovarian Cancer: Looking for new tumor biological fingerprints

Fanale, Daniele;Corsini, Lidia Rita;Bono, Marco;Randazzo, Ugo;Barraco, Nadia;Brando, Chiara;Cancelliere, Daniela;Contino, Silvia;Giurintano, Ambra;Magrin, Luigi;Pedone, Erika;Perez, Alessandro;Piraino, Paola;Pivetti, Alessia;Giovanni, Emilia Di;Russo, Tancredi Didier Bazan;Prestifilippo, Ornella;Gennusa, Vincenzo;Pantuso, Gianni;Russo, Antonio;Bazan, Viviana
2024-01-01

Abstract

Specific tumor-derived extracellular vesicles, called exosomes, are considered as potential key players in cross-talk between immune system and tumor microenvironment in several solid tumors. Different studies highlighted the clinical relevance of exosomes in ovarian cancer (OC) for their role in early diagnosis, prognosis, chemoresistance, targeted therapy. The exosomes are nanosize vesicles carrying lipids, proteins, and nucleic acids. In particular, exosomes shuttle a wide spectrum of microRNAs (miRNAs) able to induce phenotypic reprogramming of target cells, contributing to tumor progression. In this review, we will discuss the promising role of miRNAs shuttled by exosomes, called exosomal miRNAs (exo-miRNAs), as potential biomarkers for early detection, tumour progression and metastasis, prognosis, and response to therapy in OC women, in order to search for new potential biological fingerprints able to better characterize the evolution of this malignancy and provide a clinically relevant non-invasive approach useful for adopting, in future, personalized therapeutic strategies.
gen-2024
Fanale, D., Corsini, L.R., Bono, M., Randazzo, U., Barraco, N., Brando, C., et al. (2024). Clinical relevance of exosome-derived microRNAs in Ovarian Cancer: Looking for new tumor biological fingerprints [10.1016/j.critrevonc.2023.104220].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/670243
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