Apolipoprotein E is a major determinant in lipoprotein metabolism and cardiovascular disease, it has emerged as an important molecule in several biological processes including Alzheimer's disease and cognitive function. ApoE is a polymorphic protein (ε2, ε3, ε4) with three proteic isoforms, ApoE2, ApoE3, ApoE4 (1). The aim of the study was to verify the frequencies of allelic variants a population of healthy elderly people. ApoE polymorphisms were determined by Real Time-PCR. The genotype frequencies of ApoE in our group of 71 centenarians (mean age 100.9 ±1.3) were: ε2/ε3 (12.67%); ε3/ε4 (5.63%). In the control group, consisting of 97 individuals (mean age 92.98 ±2.53), the genotype frequencies were: ε2/ε3 (7.21%); ε3/ε4 (15.46%). Differences between genotype frequencies in centenarians and control group were statistically significant (P<0.05). Results confirm that the frequency of ε2 allele is increased in centenaries, suggesting that this allele could be correlated to longevity.
BELLIA, C., LO SASSO, B., CARUSO, A., LIGA, L., RAINERI, R., AGNELLO, L., et al. (2011). APOE and longevity: study of a population of Sardinian Centenarians. In Medical Biotechnologies and Forensic Medicine Review (pp. 47-52). Palermo : Plumelia.
APOE and longevity: study of a population of Sardinian Centenarians
BELLIA, Chiara;LO SASSO, Bruna;CARUSO, Antonietta;AGNELLO, Luisa;CIACCIO, Marcello
2011
Abstract
Apolipoprotein E is a major determinant in lipoprotein metabolism and cardiovascular disease, it has emerged as an important molecule in several biological processes including Alzheimer's disease and cognitive function. ApoE is a polymorphic protein (ε2, ε3, ε4) with three proteic isoforms, ApoE2, ApoE3, ApoE4 (1). The aim of the study was to verify the frequencies of allelic variants a population of healthy elderly people. ApoE polymorphisms were determined by Real Time-PCR. The genotype frequencies of ApoE in our group of 71 centenarians (mean age 100.9 ±1.3) were: ε2/ε3 (12.67%); ε3/ε4 (5.63%). In the control group, consisting of 97 individuals (mean age 92.98 ±2.53), the genotype frequencies were: ε2/ε3 (7.21%); ε3/ε4 (15.46%). Differences between genotype frequencies in centenarians and control group were statistically significant (P<0.05). Results confirm that the frequency of ε2 allele is increased in centenaries, suggesting that this allele could be correlated to longevity.
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