Editorial: Lipid alterations in cancer development, resistance and recurrence

Lipids, as well as proteins and nucleic acids, are essential for mammalian cellular biology, as they play critical roles in cellular membrane architecture, in intra- and intercellular signaling, and as fundamental energy storage. These molecular mechanisms are particularly pronounced in the context of tumors, where neoplastic cells must adapt to changes in the microenvironment, characterized by inadequate vascularization, nutrient deprivation, extracellular matrix accumulation resulting from stroma cell recruitment including immune cell infiltration, and the expansion of cancer-associated fibroblasts (CAFs).